Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study.
M, W., C, G., Q, M., S, Z., Q, C., & B, X. (2026). Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study.. Science progress. https://doi.org/10.1177/00368504261477983
M W, C G, Q M, S Z, Q C, B X. Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study.. Science progress. 2026; doi: 10.1177/00368504261477983
M W, C G, Q M, et al. Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study.[J]. Science progress. 2026. DOI: 10.1177/00368504261477983.
@article{m2026,
author = {Wang M and Guan C and Ma Q and Zhang S and Chen Q and Xiao B},
title = {Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study.},
journal = {Science progress},
year = {2026},
doi = {10.1177/00368504261477983},
note = {PMID: 42578468},
}
TY - JOUR AU - Wang M AU - Guan C AU - Ma Q AU - Zhang S AU - Chen Q AU - Xiao B TI - Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study. T2 - Science progress PY - 2026 DO - 10.1177/00368504261477983 AN - PMID:42578468 ER -
ObjectiveFrailty is prevalent in cardiovascular disease but lacks objective assessment tools in critical care. This study evaluated the association between the Frailty Index based on laboratory data (FI-LAB) at ICU admission and clinical outcomes in critically ill patients with coronary artery disease (CAD).MethodsThis retrospective cohort study used data from the MIMIC-IV and MIMIC-III Carevue databases. Patients were stratified by FI-LAB into mild (<0.25), moderate (0.25-0.4), and severe (>0.4) frailty. Multivariable logistic regression assessed in-hospital mortality, Cox models evaluated 28-day and 1-year mortality, and Fine-Gray competing risk models examined malignant arrhythmia. Dose-response relationships and subgroup effects were also assessed.ResultsAfter full adjustment, severe frailty was associated with elevated in-hospital mortality (OR = 4.41, 95% CI: 2.60-7.48, P < 0.001), 28-day mortality (HR = 3.42, 95% CI: 2.17-5.40, P < 0.001), and 1-year mortality (HR = 3.60, 95% CI: 2.56-5.06, P < 0.001). Moderate frailty similarly conferred increased risks for 28-day (HR = 1.70, P = 0.026) and 1-year mortality (HR = 2.09, P < 0.001). The Fine-Gray model showed that severe frailty was associated with a higher subdistribution hazard of malignant arrhythmia (SHR = 2.68, 95% CI: 1.39-5.18, P = 0.003). A nonlinear relationship between FI-LAB and 1-year mortality was observed (P for nonlinearity = 0.042). Results were consistent in the MIMIC-III cohort.ConclusionsHigher FI-LAB scores at ICU admission were associated with increased risks of in-hospital mortality, 28-day mortality, 1-year mortality, and malignant arrhythmia. FI-LAB may serve as a useful prognostic tool for risk stratification in critically ill patients with CAD.