Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography.
E, B., A, D., N, M.V., E, N., A, M., B, S., T, K.P., & M, O. (2026). Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography.. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia. https://doi.org/10.17392/medglas-2199-23-2
E B, A D, N MV, E N, A M, B S, et al. Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography.. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia. 2026; doi: 10.17392/medglas-2199-23-2
E B, A D, N MV, et al. Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography.[J]. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia. 2026. DOI: 10.17392/medglas-2199-23-2.
@article{e2026,
author = {Begic E and Djozic A and Mlaco-Vrazalic N and Nesimi E and Mlačo A and Stanetic B and Kovacevic-Preradovic T and Ostojic M},
title = {Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography.},
journal = {Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia},
year = {2026},
doi = {10.17392/medglas-2199-23-2},
note = {PMID: 42593004},
}
TY - JOUR AU - Begic E AU - Djozic A AU - Mlaco-Vrazalic N AU - Nesimi E AU - Mlačo A AU - Stanetic B AU - Kovacevic-Preradovic T AU - Ostojic M TI - Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography. T2 - Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia PY - 2026 DO - 10.17392/medglas-2199-23-2 AN - PMID:42593004 ER -
AIM: To investigate the relationship between coronary artery calcium (CAC) score and left ventricular global longitudinal strain (LV GLS) in patients with arterial hypertension who had a negative treadmill exercise stress test but mild to intermediate coronary stenosis on coronary computed tomography angiography (CCTA). METHODS: A total of 53 hypertensive patients (mean age 54.8 ± 4.8 years; 50.9% male) with 30-50% coronary stenosis on CCTA were included. Patients with diabetes, malignancy, or established coronary/peripheral artery disease were excluded. CAC score, left ventricular ejection fraction (LVEF, Simpson's method), and LV GLS (speckle-tracking echocardiography) were measured. Groups were stratified by GLS (< 18.5% vs. ≥ 18.5%) and LVEF (< 60% vs. ≥ 60%), and CAC score differences were assessed using the Mann-Whitney U test. RESULTS: The median CAC score was 27 (IQR 16-44.5), median LVEF 60% (IQR 58-63%), and mean GLS 19.37 ± 0.89%. No overall association was found between CAC score and LV function by LVEF or GLS. In patients with left anterior descending (LAD) stenosis (30-50%), reduced LV function was linked to significantly higher CAC score. Median CAC score was higher in patients with GLS ≤ 18.5% (157 vs. 44.5; p = 0.019) and LVEF <60% (157 vs. 44.5; p = 0.019). No significant associations were found in right coronary artery (RCA), circumflex artery (Cx), or three-vessel stenosis subgroups. CONCLUSION: Higher CAC score in hypertensive patients with mild LAD stenosis and negative stress testing identify those at risk of subclinical LV dysfunction.