Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis.
J, C., X, S., Y, L., J, M., & X, S. (2026). Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis.. Gynecological endocrinology : the official journal of the International Society of Gynecological End. https://doi.org/10.1080/09513590.2026.2693409
J C, X S, Y L, J M, X S. Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis.. Gynecological endocrinology : the official journal of the International Society of Gynecological End. 2026; doi: 10.1080/09513590.2026.2693409
J C, X S, Y L, et al. Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis.[J]. Gynecological endocrinology : the official journal of the International Society of Gynecological End. 2026. DOI: 10.1080/09513590.2026.2693409.
@article{j2026,
author = {Chen J and Shen X and Li Y and Ma J and Shen X},
title = {Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis.},
journal = {Gynecological endocrinology : the official journal of the International Society of Gynecological End},
year = {2026},
doi = {10.1080/09513590.2026.2693409},
note = {PMID: 42605867},
}
TY - JOUR AU - Chen J AU - Shen X AU - Li Y AU - Ma J AU - Shen X TI - Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis. T2 - Gynecological endocrinology : the official journal of the International Society of Gynecological End PY - 2026 DO - 10.1080/09513590.2026.2693409 AN - PMID:42605867 ER -
OBJECTIVE: Endometriosis faces diagnostic delays due to the lack of tools for diagnostic evaluation. The value of miR-4677-3p combined with ultrasound in the diagnosis of endometriosis. METHODS: 110 healthy subjects and 110 endometriosis patients were recruited. miR-4677-3p level was detected by qRT-PCR. Color Doppler ultrasound was used to measure uterine artery blood flow parameters. Pearson analysis was applied to explore the correlation between miR-4677-3p and blood flow parameters. ROC curve was used to evaluate the diagnostic value. Logistic regression analysis was performed to identify risk factors. RESULTS: miR-4677-3p serum expression in endometriosis patients was upregulated, EDV and PSV were decreased, while PI and RI were increased. miR-4677-3p level was negatively correlated with RI and PI, and positively correlated with EDV and PSV. miR-4677-3p has diagnostic value for endometriosis, with an AUC of 0.863. After combination with ultrasound parameters, the AUC increased to 0.925, indicating a superior diagnostic value for endometriosis. Aberrantly expressed miR-4677-3p, dysmenorrhea, and CA125 as risk factors. CONCLUSION: The combined application of serum miR-4677-3p and ultrasound parameters can improve the diagnostic efficiency of endometriosis, providing a clinical tool for the accurate identification of the disease.