Glycosylation in gut-brain communication: from the intestinal barrier and microbiota to immune and neural signaling.
The gut-brain axis is a complex bidirectional communication network linking the gastrointestinal tract and the central nervous system. Its dysregulation is closely associated with a wide range of gast...
Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis.
OBJECTIVE: Endometriosis faces diagnostic delays due to the lack of tools for diagnostic evaluation. The value of miR-4677-3p combined with ultrasound in the diagnosis of endometriosis. METHODS: 110 h...
Ultrasound-triggered platelet vehicles loading fluorescein for targeted sonodynamic therapy of glioblastoma.
Glioblastoma (GBM), the deadliest primary brain malignancy, resists treatment because of the blood‒brain barrier (BBB) and intrinsic resistance mechanisms. Fluorescein (FL), a clinically approved fluo...
Beyond the pump: integrating the heart's endocrine function into early medical education.
BACKGROUND: The heart is commonly introduced in early medical education through its structural, mechanical, and electrophysiological roles. Although this framing remains foundational, it may underemph...
Adiponectin improves the aortic dissection by inhibiting inflammatory cell infiltration and macrophage pyroptosis.
OBJECTIVE: Aortic dissection (AD) is a fatal cardiovascular emergency that is predominantly induced by long-term uncontrolled hypertension. MATERIALS AND METHODS: The mouse AD model was established by...
The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.
OBJECTIVES: Iron overload (IO) cardiomyopathy is a major cause of mortality in patients with iron overload disorders. This study investigates the role of cystathionine γ-lyase (CSE), a key enzyme in t...
Low-intensity pulsed ultrasound combined with microbubbles enhances amphotericin B delivery across the blood-brain barrier for improved therapy of cryptococcal meningitis.
Cryptococcal meningitis (CM), a life-threatening fungal infection of the central nervous system, faces therapeutic challenges due to poor blood‒brain barrier (BBB) penetration of amphotericin B. This ...
Efficient brain delivery and sustained retention of antibodies via dual targeting of blood-brain barrier and intra-brain proteins.
Efficient delivery of therapeutic antibodies to the brain has been increasingly achieved using receptor-mediated transcytosis (RMT) approaches such as transferrin receptor (TfR)-mediated shuttle syste...
The needle-puncture mouse aortocaval AVF model: a state of the art review.
Recent advances using the mouse needle-puncture aortocaval arteriovenous fistula (AVF) model have enhanced our understanding of the complex pathological changes occurring at the juxta-anastomotic area...
Integrative transcriptomic and single-cell analysis identifies anoikis-related molecular signatures in vascular calcification.
BACKGROUND: Vascular calcification (VC) is a life-threatening complication of chronic kidney disease (CKD) driven by vascular smooth muscle cell (VSMC) osteogenic transdifferentiation. Anoikis, a form...
Noninvasive assessment of Doppler-derived estimated fetal interatrial pressure-gradient indices using ductus venosus and pulmonary vein velocities in late-onset fetal growth restriction: a prospective case-control study.
BACKGROUND: Fetal growth restriction (FGR) is associated with progressive hemodynamic deterioration and subclinical cardiac dysfunction. The modified Bernoulli equation applied to ductus venosus and p...
Controversies in the management of fetal growth restriction: a state-of-the-art review.
Fetal growth restriction (FGR) affects 5%-10% of pregnancies and remains a major contributor to stillbirth, neonatal morbidity, and long-term adverse outcomes. Despite its clinical importance, substan...
Association between perioperative D-dimer dynamics and post-treatment localized intravascular coagulation in venous malformations.
OBJECTIVE: To investigate the association between the change in D-dimer levels (ΔD-dimer) and the development of localized intravascular coagulation (LIC) following surgical intervention in patients w...
Early hemodynamic assessment and longitudinal imaging for predicting graft outcomes post-transplant.
BACKGROUND: The early identification of early allograft dysfunction (EAD) and the long-term prediction of graft-related adverse event-free survival (GRAEFS) are crucial for effective post-transplant m...
Placental 3D Doppler and uterine artery Doppler for predicting adverse outcomes in placenta accreta: a retrospective cohort study.
BACKGROUND: Placenta accreta spectrum (PAS) poses high maternal morbidity from adverse pregnancy outcomes (APOs), yet uterine artery Doppler has limited predictive value, and the additive role of thre...
Environmental cues signal through circadian control of sarcomeric gene expression during cardiomyocyte hypertrophy.
Environmental disruption alters circadian clock gene expression, increasing the risk of adverse cardiac events and suggesting cardiomyocyte-specific circadian responses to external stimuli. Analyses o...
The predictive value of the TAPSE/PASP ratio for major adverse cardiovascular events in patients with chronic heart failure: evidence from a prolonged follow-up cohort.
BACKGROUND: The tricuspid annular plane systolic excursion to pulmonary artery systolic pressure (TAPSE/PASP) ratio is a noninvasive surrogate of right ventricular-pulmonary arterial coupling. Previou...
Astrocyte exosomes shield retina from ischemia via CaMKII-autophagy.
BACKGROUND: Retinal ischemia-reperfusion (RIR) injury impairs vision through microvascular damage and inflammation. While astrocyte-derived exosomes (ADEs) offer neuroprotection, their role in protect...
Determinants, risk score, and prognostic implications of left ventricular thrombus in ischemic cardiomyopathy assessed by cardiac magnetic resonance: a retrospective cohort study.
BACKGROUND: Left ventricular thrombus (LVT) is a significant complication in ischemic cardiomyopathy (ICM). However, factors associated with LVT have mainly been reported in patients with recent myoca...
A hybrid biofabrication platform for patient-specific aortic phantoms: from surgical rehearsal to device testing.
Fabricating high-fidelity, patient-specific aortic phantoms that possess both complex pathological features and physiological compliance remains a significant challenge for single-method manufacturing...