Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis.
WA, S., PA, O., TA, A., BT, O., AO, O., MD, O., CA, I., OM, O., S, O., & JA, N. (2026). Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis.. Antonie van Leeuwenhoek. https://doi.org/10.1007/s10482-026-02349-z
WA S, PA O, TA A, BT O, AO O, MD O, et al. Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis.. Antonie van Leeuwenhoek. 2026; doi: 10.1007/s10482-026-02349-z
WA S, PA O, TA A, et al. Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis.[J]. Antonie van Leeuwenhoek. 2026. DOI: 10.1007/s10482-026-02349-z.
@article{wa2026,
author = {Saka WA and Oyedokun PA and Alade TA and Oyeleke BT and Oyelaran AO and Oyedokun MD and Irozuoke CA and Olayemi OM and Oladepo S and Ndako JA},
title = {Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis.},
journal = {Antonie van Leeuwenhoek},
year = {2026},
doi = {10.1007/s10482-026-02349-z},
note = {PMID: 42203993},
}
TY - JOUR AU - Saka WA AU - Oyedokun PA AU - Alade TA AU - Oyeleke BT AU - Oyelaran AO AU - Oyedokun MD AU - Irozuoke CA AU - Olayemi OM AU - Oladepo S AU - Ndako JA TI - Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis. T2 - Antonie van Leeuwenhoek PY - 2026 DO - 10.1007/s10482-026-02349-z AN - PMID:42203993 ER -
Despite the increasing burden of mortality due to cardiovascular disease, the traditional risk factors fail to explain the complexity of the pathology of cardiovascular disease, especially in the context of chronic inflammation. Emerging scientific evidence indicates that dysbiosis of the oral, gut, and reproductive microbiome is associated with systemic vascular dysfunction. This review comprehensively discusses the available scientific data on the interactions between the mucosal colonizing microbiota and their modulation of whole-body inflammation and cardiovascular disease pathogenesis. It underlines the roles of microbial metabolites, including trimethylamine N-oxide and lipopolysaccharides, in immune activation, epithelial barrier cell injury, and their effects in endothelial activation, vascular remodeling and dysfunction, oxidative stress, and inflammation. This review describes the mechanistic interplay that drives atherosclerosis and vascular dysfunction, mediated by immune activation and cytokine-driven inflammatory cascades. Sex hormones influence the composition of the microbiota and the host immune responses, thereby influencing vascular disease manifestations and responses to therapy. These mechanisms present the potential of intervening at the microbial crossroads through microbiome-targeted approaches as an effective treatment strategy for cardiovascular disease.