miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.
M, I., M, H., M, H., F, R., EPC, v.d.V., C, W., & K, B. (2026). miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.. International journal of molecular sciences. https://doi.org/10.3390/ijms27104644
M I, M H, M H, F R, EPC vdV, C W, et al. miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.. International journal of molecular sciences. 2026; doi: 10.3390/ijms27104644
M I, M H, M H, et al. miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.[J]. International journal of molecular sciences. 2026. DOI: 10.3390/ijms27104644.
@article{m2026,
author = {Igl M and Haberbosch M and Hristov M and Reich F and van der Vorst EPC and Weber C and Bidzhekov K},
title = {miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.},
journal = {International journal of molecular sciences},
year = {2026},
doi = {10.3390/ijms27104644},
note = {PMID: 42196619},
}
TY - JOUR AU - Igl M AU - Haberbosch M AU - Hristov M AU - Reich F AU - van der Vorst EPC AU - Weber C AU - Bidzhekov K TI - miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions. T2 - International journal of molecular sciences PY - 2026 DO - 10.3390/ijms27104644 AN - PMID:42196619 ER -
Endothelial cell dysfunction is the initial step in atherosclerosis, in which gap junction proteins such as connexin 40 (Cx40) might play an important role. Previously, we could demonstrate that miRNA-26b, a 21-nucleotide miRNA, is highly expressed in human atherosclerotic plaques and plays a key causal role in atherogenesis. There is evidence that miRNA-26b and Cx40 play crucial roles in sustaining endothelial health. However, their potential effects on atherosclerosis-related processes remain poorly understood. Therefore, this study elucidated the expression of miRNA-26b and Cx40 and studied the effect of Cx40 on inflammation and monocyte binding, which are key processes in atherosclerosis formation. In a human in vitro endothelial cell model, miRNA-26b overexpression is associated with increased Cx40 expression. Although we did not observe any anti-atherogenic effect of Cx40 on monocyte attachment or VCAM-1 transcription under static conditions, a flow-dependent expression pattern characterised by increased Cx40 and reduced VCAM-1 transcription was observed. How miRNA-26b and Cx40 are connected remains to be investigated. Furthermore, the functional role of Cx40 under flow conditions requires further investigation.