Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.
J, X., O, G., S, B., R, H., M, S., M, L., U, S., & T, H. (2026). Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.. Journal of cardiovascular translational research. https://doi.org/10.1007/s12265-026-10778-4
J X, O G, S B, R H, M S, M L, et al. Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.. Journal of cardiovascular translational research. 2026; doi: 10.1007/s12265-026-10778-4
J X, O G, S B, et al. Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.[J]. Journal of cardiovascular translational research. 2026. DOI: 10.1007/s12265-026-10778-4.
@article{j2026,
author = {Xie J and Gemeinhardt O and Bettink S and Hauptmann R and Schannor M and Loechel M and Speck U and Haase T},
title = {Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.},
journal = {Journal of cardiovascular translational research},
year = {2026},
doi = {10.1007/s12265-026-10778-4},
note = {PMID: 42191941},
}
TY - JOUR AU - Xie J AU - Gemeinhardt O AU - Bettink S AU - Hauptmann R AU - Schannor M AU - Loechel M AU - Speck U AU - Haase T TI - Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing. T2 - Journal of cardiovascular translational research PY - 2026 DO - 10.1007/s12265-026-10778-4 AN - PMID:42191941 ER -
The porcine in-stent stenosis model has been essential for developing drug-coated devices but does not replicate the hyperlipidemic, pro-atherogenic conditions driving neoatherosclerosis. We aimed to establish a practical porcine model for testing endovascular therapies targeting neoatherosclerosis. Juvenile pigs were fed a high-fat, nicotine-supplemented diet (HFDN). After two weeks, bare-metal stents were implanted in coronary and peripheral arteries; controls received a standard diet. Four weeks later, stented, and non-stented artery segments were analyzed. HFDN feeding induced elevated serum LDL and cotinine. At follow-up, in-stent late lumen loss was significantly greater in peripheral arteries (A. iliaca: 2.3 ± 0.6 vs. 1.1 ± 0.5 mm; A. femoralis: 3.4 ± 1.2 vs. 2.0 ± 0.4 mm), but not coronary arteries. HFDN-fed pigs showed distinct signs of early neoatherosclerosis, including peri-strut foam cell accumulations and atheroma formation. Elemental imaging and chemical analysis confirmed increased calcium phosphate deposition in arteries of HFDN-fed pigs. This straightforward protocol enables testing of devices aimed at preventing or treating neoatherosclerosis.