The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.
Y, S., W, W., C, W., & X, Z. (2026). The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.. Journal of cardiothoracic surgery. https://doi.org/10.1186/s13019-026-04629-1
Y S, W W, C W, X Z. The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.. Journal of cardiothoracic surgery. 2026; doi: 10.1186/s13019-026-04629-1
Y S, W W, C W, et al. The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.[J]. Journal of cardiothoracic surgery. 2026. DOI: 10.1186/s13019-026-04629-1.
@article{y2026,
author = {Shi Y and Wang W and Weng C and Zhang X},
title = {The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.},
journal = {Journal of cardiothoracic surgery},
year = {2026},
doi = {10.1186/s13019-026-04629-1},
note = {PMID: 42618935},
}
TY - JOUR AU - Shi Y AU - Wang W AU - Weng C AU - Zhang X TI - The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure. T2 - Journal of cardiothoracic surgery PY - 2026 DO - 10.1186/s13019-026-04629-1 AN - PMID:42618935 ER -
OBJECTIVE: Patients with chronic heart failure (CHF) have a high mortality rate. The aim of this research is to examine the clinical value and molecular mechanisms of the lncRNA T cell receptor gamma chain-associated AS1 (TRG-AS1) in CHF. METHODS: The TRG-AS1 expression in 116 CHF patients was assessed by qRT-PCR. The diagnostic and prognostic value of TRG-AS1 was evaluated through ROC and COX survival analysis. The correlation between TRG-AS1 and clinical parameters was examined using Pearson's correlation analysis. Cell growth and death were assessed using the CCK-8 assay and double-staining methods. ELISA was used to detect inflammatory factors. The DLR assay was used to verify the interaction between TRG-AS1, miR-139-5p, and RUNX1. RESULTS: TRG-AS1 is upregulated in CHF (P < 0.0001) and is positively correlated with BNP (r = 0.500, P < 0.0001) and CRP levels (r = 0.398, P < 0.0001), while negatively correlated with LVEF (r=-0.605, P < 0.0001). TRG-AS1 is an risk factor for poor patient prognosis (HR = 3.043, 95%CI: 1.359-6.816, P = 0.007) and possesses good diagnostic value (AUC = 0.895, 95%CI: 0.852-0.938, Sensitivity: 84.5%, Specificity: 80.0%, P < 0.0001). Knocking out TRG-AS1 enhances cell proliferation, reduces apoptosis, alleviates oxidative stress, and inhibits the release of inflammatory factors by reducing the binding to miR-139-5p (P < 0.01). CONCLUSION: TRG-AS1 may serve as a new diagnostic biomarker for CHF. The TRG-AS1/miR-139-5p axis may represent a potential therapeutic target for CHF. Furthermore, RUNX1 has been preliminarily identified as a downstream target gene of this ceRNA.