Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.
A, I., E, V., L, C., S, K., Z, J., G, M., A, U., S, A., M, B., & A, K. (2026). Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.. Journal of translational medicine. https://doi.org/10.1186/s12967-026-08739-1
A I, E V, L C, S K, Z J, G M, et al. Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.. Journal of translational medicine. 2026; doi: 10.1186/s12967-026-08739-1
A I, E V, L C, et al. Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.[J]. Journal of translational medicine. 2026. DOI: 10.1186/s12967-026-08739-1.
@article{a2026,
author = {Issilbayeva A and Vinogradova E and Chulenbayeva L and Kozhakhmetov S and Jarmukhanov Z and Myrzakhmetova G and Umriukhin A and Andossova S and Bekbossynova M and Kushugulova A},
title = {Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.},
journal = {Journal of translational medicine},
year = {2026},
doi = {10.1186/s12967-026-08739-1},
note = {PMID: 42618929},
}
TY - JOUR AU - Issilbayeva A AU - Vinogradova E AU - Chulenbayeva L AU - Kozhakhmetov S AU - Jarmukhanov Z AU - Myrzakhmetova G AU - Umriukhin A AU - Andossova S AU - Bekbossynova M AU - Kushugulova A TI - Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis. T2 - Journal of translational medicine PY - 2026 DO - 10.1186/s12967-026-08739-1 AN - PMID:42618929 ER -
BACKGROUND: Obesity is widely recognized as an aggravating risk factor for atherosclerosis (AS), yet the effects of obesity on AS-associated microbiome dysbiosis are not sufficiently characterized. This study aims to identify the contribution of obesity-related dysbiosis in AS. METHODS: Using shotgun metagenomic sequencing, we studied gut microbiome composition and functional capacity across non-obese AS patients (AS-NOB, BMI < 30, n = 93), age-sex-matched non-obese controls (Ctrl-NOB, BMI < 30, n = 27), and obese AS patients (AS-OB, BMI ≥ 30, n = 68). RESULTS: Gut community composition differed significantly across study groups (PERMANOVA F = 3.23, p = 0.001). Among metadata, obesity had the strongest effect (F = 3.1, p < 0.01) on the microbiome structure of AS patients. Furthermore, obese AS patients demonstrated a decrease in species richness and evenness (p < 0.05). Taxonomic and functional analysis further suggested that obesity does not simply aggravate AS-associated gut dysbiosis but instead redirects it towards a distinct community state, characterized by a Prevotella expansion that consistently opposes the rest of the bacterial community. Among AS microbiome markers, an increase was detected in Pseudomonadota (Proteobacteria), Bilophila, Dysosmobacter, and Faecalibacterium. CONCLUSION: Taken together, these results suggest that pathological expansion of Prevotella, potentially in conjunction with reduced alpha diversity, may represent a putative indicator of increased risk in AS patients, particularly within populations where the Prevotella enterotype or subtype is prevalent, warranting further investigation.