Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study.
X, Z., Z, Z., X, Y., X, Z., H, L., Y, L., S, W., F, G., F, Y., & J, C. (2026). Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study.. Frontiers in endocrinology. https://doi.org/10.3389/fendo.2026.1852416
X Z, Z Z, X Y, X Z, H L, Y L, et al. Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study.. Frontiers in endocrinology. 2026; doi: 10.3389/fendo.2026.1852416
X Z, Z Z, X Y, et al. Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study.[J]. Frontiers in endocrinology. 2026. DOI: 10.3389/fendo.2026.1852416.
@article{x2026,
author = {Zhang X and Zhang Z and Yu X and Zhang X and Liu H and Le Y and Wang S and Gao F and Yang F and Chen J},
title = {Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study.},
journal = {Frontiers in endocrinology},
year = {2026},
doi = {10.3389/fendo.2026.1852416},
note = {PMID: 42630158},
}
TY - JOUR AU - Zhang X AU - Zhang Z AU - Yu X AU - Zhang X AU - Liu H AU - Le Y AU - Wang S AU - Gao F AU - Yang F AU - Chen J TI - Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study. T2 - Frontiers in endocrinology PY - 2026 DO - 10.3389/fendo.2026.1852416 AN - PMID:42630158 ER -
BACKGROUND: There exists a close and complex bidirectional relationship between cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD is a well-established risk factor for CKD, while the Triglyceride glucose-body mass index (TyG-BMI) has been considered as a predictor of cardiovascular events. This was a retrospective case-control study. This study aimed to investigate the relationship between preoperative TyG-BMI and estimated glomerular filtration rate(eGFR) during follow-up in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). METHODS: This study was performed in 1020 patients with CHD after PCI without CKD from 01/01/2015 to 01/01/2025. We performed multifaceted analyses of the association between preoperative TyG-BMI and eGFR, including multiple linear regression for continuous eGFR outcomes, logistic regression to identify whether TyG-BMI independently influenced categorical eGFR status and quantify the magnitude of this association, and restricted cubic spline (RCS) analysis to explore non-linear relationships. Low eGFR (<60 mL/(min*1.73m²)) was set as the outcome variable, and was obtained from the latest follow-up. RESULTS: The multivariate linear regression analysis revealed no statistically significant linear association between preoperative TyG-BMI and eGFR (t = -1.850, P = 0.065). Logistic regression indicated that TyG-BMI was not identified as an independent influencing factor of eGFR (P = 0.369, OR = 1.003, 95%CI:0.977~1.009). RCS analysis indicated that the nonlinear association between TyG-BMI and eGFR was not statistically significant (P for nonlinear > 0.05). CONCLUSION: Preoperative TyG-BMI exerted no direct independent effect on long-term outcome of eGFR. It is unlikely that TyG-BMI serves as a primary determinant of CKD in patients with CHD after PCI. Future studies should evaluate combined risk models.