Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study.
T, S., B, L., X, L., C, P., Y, W., W, S., H, C., S, H., & H, S. (2026). Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study.. Journal of cardiovascular translational research. https://doi.org/10.1007/s12265-026-10833-0
T S, B L, X L, C P, Y W, W S, et al. Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study.. Journal of cardiovascular translational research. 2026; doi: 10.1007/s12265-026-10833-0
T S, B L, X L, et al. Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study.[J]. Journal of cardiovascular translational research. 2026. DOI: 10.1007/s12265-026-10833-0.
@article{t2026,
author = {Shi T and Liu B and Lian X and Peng C and Wang Y and Shi W and Chen H and He S and Sun H},
title = {Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study.},
journal = {Journal of cardiovascular translational research},
year = {2026},
doi = {10.1007/s12265-026-10833-0},
note = {PMID: 42635873},
}
TY - JOUR AU - Shi T AU - Liu B AU - Lian X AU - Peng C AU - Wang Y AU - Shi W AU - Chen H AU - He S AU - Sun H TI - Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study. T2 - Journal of cardiovascular translational research PY - 2026 DO - 10.1007/s12265-026-10833-0 AN - PMID:42635873 ER -
Atrial fibrillation (AF) is the most common clinical arrhythmia. Patients with paroxysmal atrial fibrillation (PAF) may exhibit reversible changes in atrial function at an early stage. Identifying biomarkers for this stage is crucial for delaying disease progression. This study integrated cardiac magnetic resonance (CMR) atrial strain analysis with untargeted metabolomics. Despite similar left atrial sizes, significant differences in atrial strain were observed among PAF patients. Seven differential metabolites-phosphatidylcholine, inosine, bilirubin, biliverdin, 3-methylhistidine, L-tryptophan, and pantothenic acid-were identified as potential biomarkers associated with declining atrial function. These findings suggest that peripheral blood metabolites are associated with atrial functional impairment in PAF patients. However, these exploratory findings warrant further investigation in larger prospective cohorts.