Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure.
Andrea, S., Lucia, T., Matteo, B., Valentina, M., Cristina, C.M., Giuseppe, A., Umberto, A., Giuseppe, A., Roberto, B., Michele, C., Matteo, C.M., Giulia, C., Giuseppe, D., Mariafrancesca, D.S., Francesco, F., Stefano, G., Maria, I.R., Francesco, L., Damiano, M., . . . Michele, C. (2026). Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure.. Heart failure reviews. https://doi.org/10.1007/s10741-026-10667-7
Andrea S, Lucia T, Matteo B, Valentina M, Cristina CM, Giuseppe A, et al. Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure.. Heart failure reviews. 2026; doi: 10.1007/s10741-026-10667-7
Andrea S, Lucia T, Matteo B, et al. Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure.[J]. Heart failure reviews. 2026. DOI: 10.1007/s10741-026-10667-7.
@article{andrea2026,
author = {Salzano Andrea and Tricarico Lucia and Beltrami Matteo and Mercurio Valentina and Carella Maria Cristina and Ambrosio Giuseppe and Attanasio Umberto and Armentaro Giuseppe and Badagliacca Roberto and Ciccarelli Michele and Ciccone Marco Matteo and Crisci Giulia and Dattilo Giuseppe and Di Santo Mariafrancesca and Fioretti Francesco and Ghio Stefano and Inciardi Riccardo Maria and Loria Francesco and Magrì Damiano and Paolillo Stefania and Parati Gianfranco and Ruocco Gaetano Maria and Sciacqua Angela and Severino Paolo and Tocchetti Carlo Gabriele and Vizza Carmine Dario and Agostoni Piergiuseppe and Barillà Francesco and Dini Frank Lloyd and Carluccio Erberto and Filardi Pasquale Perrone and Nodari Savina and Palazzuoli Alberto and Sinagra Gianfranco and Correale Michele},
title = {Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure.},
journal = {Heart failure reviews},
year = {2026},
doi = {10.1007/s10741-026-10667-7},
note = {PMID: 42669762},
}
TY - JOUR AU - Salzano Andrea AU - Tricarico Lucia AU - Beltrami Matteo AU - Mercurio Valentina AU - Carella Maria Cristina AU - Ambrosio Giuseppe AU - Attanasio Umberto AU - Armentaro Giuseppe AU - Badagliacca Roberto AU - Ciccarelli Michele AU - Ciccone Marco Matteo AU - Crisci Giulia AU - Dattilo Giuseppe AU - Di Santo Mariafrancesca AU - Fioretti Francesco AU - Ghio Stefano AU - Inciardi Riccardo Maria AU - Loria Francesco AU - Magrì Damiano AU - Paolillo Stefania AU - Parati Gianfranco AU - Ruocco Gaetano Maria AU - Sciacqua Angela AU - Severino Paolo AU - Tocchetti Carlo Gabriele AU - Vizza Carmine Dario AU - Agostoni Piergiuseppe AU - Barillà Francesco AU - Dini Frank Lloyd AU - Carluccio Erberto AU - Filardi Pasquale Perrone AU - Nodari Savina AU - Palazzuoli Alberto AU - Sinagra Gianfranco AU - Correale Michele TI - Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure. T2 - Heart failure reviews PY - 2026 DO - 10.1007/s10741-026-10667-7 AN - PMID:42669762 ER -
Heart failure (HF) and cardiovascular (CV) diseases (CVD) are closely interconnected through a complex and bidirectional relationship. HF frequently represents the final common pathway of several CV conditions; in contrast, CV comorbidities often act as key drivers of disease progression along the HF continuum, from stage A (individuals at risk) to overt symptomatic HF (stages C-D). The coexistence of multiple CV comorbidities-including arterial hypertension, atrial fibrillation, coronary artery disease, peripheral artery disease, and valvular heart disease-is associated with a more severe clinical profile, reduced functional capacity, impaired quality of life, and increased risk of hospitalization and mortality. Importantly, CV comorbidities may significantly influence the implementation and optimization of guideline-directed medical therapy (GDMT), frequently limiting appropriate up-titration due to haemodynamic instability, drug intolerance, or increased susceptibility to adverse events. The prevalence, pathophysiological interactions, and prognostic impact of CV comorbidities vary across HF phenotypes, contributing to the heterogeneity of disease presentation and clinical outcomes. An integrated and phenotype-oriented approach is therefore essential to optimize risk stratification and personalize therapeutic strategies. Since the publication of the 2019 manifesto on HF comorbidities from the Working Group on Heart Failure of the Italian Society of Cardiology (SIC), substantial new evidence has emerged regarding the epidemiology, pathophysiology, and management of CV comorbidities in HF. In this updated position paper, the SIC Working Group on Heart Failure provides a comprehensive and clinically oriented overview of the current evidence on major CV comorbidities in HF, with the aim of supporting clinicians in improving diagnostic pathways, optimizing therapeutic strategies, and ultimately enhancing clinical outcomes.