Toufik, A.R., Poulami, R., Neil, G., Abubakar, N., Samirkumar, M.K., Ajit, D.N., Shamaila, H., Renitha, R., Gautham, K.S., Patrick, A., J, L.C., & Rahul, G. (2026). Gene editing for inherited cardiac conditions: A new frontier in cardiology.. Trends in cardiovascular medicine. https://doi.org/10.1016/j.tcm.2025.11.002
Toufik AR, Poulami R, Neil G, Abubakar N, Samirkumar MK, Ajit DN, et al. Gene editing for inherited cardiac conditions: A new frontier in cardiology.. Trends in cardiovascular medicine. 2026; doi: 10.1016/j.tcm.2025.11.002
Toufik AR, Poulami R, Neil G, et al. Gene editing for inherited cardiac conditions: A new frontier in cardiology.[J]. Trends in cardiovascular medicine. 2026. DOI: 10.1016/j.tcm.2025.11.002.
@article{toufik2026,
author = {Abdul-Rahman Toufik and Roy Poulami and Garg Neil and Nazir Abubakar and Mehta Kahan Samirkumar and Doshi Neel Ajit and Hassnain Shamaila and Reddi Renitha and Kanagala Sai Gautham and Ashinze Patrick and Lavie Carl J and Gupta Rahul},
title = {Gene editing for inherited cardiac conditions: A new frontier in cardiology.},
journal = {Trends in cardiovascular medicine},
year = {2026},
doi = {10.1016/j.tcm.2025.11.002},
note = {PMID: 41237872},
}
TY - JOUR AU - Abdul-Rahman Toufik AU - Roy Poulami AU - Garg Neil AU - Nazir Abubakar AU - Mehta Kahan Samirkumar AU - Doshi Neel Ajit AU - Hassnain Shamaila AU - Reddi Renitha AU - Kanagala Sai Gautham AU - Ashinze Patrick AU - Lavie Carl J AU - Gupta Rahul TI - Gene editing for inherited cardiac conditions: A new frontier in cardiology. T2 - Trends in cardiovascular medicine PY - 2026 DO - 10.1016/j.tcm.2025.11.002 AN - PMID:41237872 ER -
Inherited cardiac conditions (ICCs) such as hypertrophic cardiomyopathy and Marfan syndrome pose significant global health challenges, often rooted in complex genetic mutations. Recent advances in gene editing, particularly the CRISPR/Cas9 system, have opened new avenues for precise, personalized interventions. This review examines the current landscape of gene editing in cardiology, with emphasis on its scientific promise, integration with epigenetics, gene therapy, and artificial intelligence, and its potential to transform clinical outcomes. Key gene editing strategies are analyzed for their efficacy and translational potential. The review also explores ongoing clinical trials and emerging research, offering practical insights for future studies. Ethical implications are critically evaluated, with proposed frameworks to address concerns around safety, equity, and long-term consequences. By synthesizing these developments, this review underscores the urgent need for continued interdisciplinary research in the quest to mitigate inherited cardiac diseases.