Joint Relationship of Cardiovascular-kidney-metabolic Syndrome and Psoriasis with All-cause and Cause-specific Mortality in Adults: A Population-based Analysis.
J, Z., H, G., B, H., Y, W., & H, X. (2026). Joint Relationship of Cardiovascular-kidney-metabolic Syndrome and Psoriasis with All-cause and Cause-specific Mortality in Adults: A Population-based Analysis.. Acta dermato-venereologica. https://doi.org/10.2340/actadv.v106.adv-2025-0241
J Z, H G, B H, Y W, H X. Joint Relationship of Cardiovascular-kidney-metabolic Syndrome and Psoriasis with All-cause and Cause-specific Mortality in Adults: A Population-based Analysis.. Acta dermato-venereologica. 2026; doi: 10.2340/actadv.v106.adv-2025-0241
J Z, H G, B H, et al. Joint Relationship of Cardiovascular-kidney-metabolic Syndrome and Psoriasis with All-cause and Cause-specific Mortality in Adults: A Population-based Analysis.[J]. Acta dermato-venereologica. 2026. DOI: 10.2340/actadv.v106.adv-2025-0241.
@article{j2026,
author = {Zhou J and Ge H and Huang B and Wang Y and Xiang H},
title = {Joint Relationship of Cardiovascular-kidney-metabolic Syndrome and Psoriasis with All-cause and Cause-specific Mortality in Adults: A Population-based Analysis.},
journal = {Acta dermato-venereologica},
year = {2026},
doi = {10.2340/actadv.v106.adv-2025-0241},
note = {PMID: 42272193},
}
TY - JOUR AU - Zhou J AU - Ge H AU - Huang B AU - Wang Y AU - Xiang H TI - Joint Relationship of Cardiovascular-kidney-metabolic Syndrome and Psoriasis with All-cause and Cause-specific Mortality in Adults: A Population-based Analysis. T2 - Acta dermato-venereologica PY - 2026 DO - 10.2340/actadv.v106.adv-2025-0241 AN - PMID:42272193 ER -
Psoriasis has been associated with cardiovascular risk, but the combined association of psoriasis and cardiovascular-kidney-metabolic (CKM) syndrome with mortality remains unclear. This study examined the individual and joint associations of CKM syndrome and self-reported psoriasis with allcause and cardio-cerebrovascular disease (CCD) mortality among 9,598 U.S. adults aged ≥20 years from NHANES 2003-2006 and 2009-2014. CKM syndrome stages were defined according to the 2023 American Heart Association framework, and psoriasis was assessed by self-reported physician diagnosis. Mortality was ascertained through linkage to the National Death Index through 2019. During a median follow-up of 9.3 years, 860 deaths occurred. Advanced CKM syndrome was associated with higher all-cause mortality (HR=3.67; 95% CI: 3.00-4.50) and CCD mortality (HR=8.16; 95% CI: 5.42-12.28). Psoriasis was also associated with higher all-cause mortality (HR=2.06; 95% CI: 1.47-2.90) and CCD mortality (HR=2.69; 95% CI: 1.42-5.08). Participants with both advanced CKM syndrome and psoriasis had the highest observed risks of all-cause mortality (HR=7.09; 95% CI: 4.93-10.19) and CCD mortality (HR=16.47; 95% CI: 7.26-37.33). Formal interaction testing did not show significant multi-plicative interaction for all-cause mortality (p for interaction=0.16) or CCD mortality (p for interaction=0.80). These findings suggest that coexisting advanced CKM syndrome and psoriasis may identify adults with particularly elevated mortality risk.