The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders.

BACKGROUND: Bipolar disorders (BD) rank among the most disabling conditions, affecting millions worldwide. Cognitive impairment in BD is linked with brain changes and worse functional outcomes. Obesit...

Selected Retinal and Choroidal Parameters Assessed by Optical Coherence Tomography and Optical Coherence Tomography Angiography in Patients With Obstructive Sleep Apnea.

BACKGROUND The aim of this study was to assess selected retinal parameters and choroidal thickness in patients with obstructive sleep apnea. MATERIAL AND METHODS Forty-nine patients (98 eyes) were inc...

Trefoil Factor 3 as a Biomarker for Peripheral Artery Disease.

BACKGROUND: While trefoil factor 3 (TFF3) has been linked to cardiovascular disease, its role in peripheral artery disease (PAD) remains largely unexplored. In this prospective study, we assessed thre...

Single-Lead ECG Arrhythmia Classification Based on Peak-Enhanced Attention Network and Quality-Aware GAN Data Augmentation Framework.

Single-lead electrocardiogram (ECG) is widely used in wearable devices for atrial fibrillation (AF) screening. Nevertheless, subtle pathological characteristics like P-waves and f-waves in practical s...

Rare Truncating HAND2 Variants Predispose to Atrial Fibrillation.

Background/Objectives: As the most prevalent supraventricular arrhythmia, affecting around 1% of people worldwide, atrial fibrillation (AF) is implicated with a multitude of detrimental clinical seque...

Reducing Lower Extremity Amputations via Peer Support Interventions: A Scoping Review.

Patients with diabetes and/or peripheral artery disease (PAD) are at risk for lower limb amputation and a subsequently higher mortality risk. Peer support interventions have been shown to increase dia...

KNG-1, HSPG and Robo4 reflect hypertension-driven subclinical renal alterations and provide incremental diagnostic value in type 2 diabetic nephropathy.

Diabetic nephropathy (DN), indicated by persistent urinary albumin excretion or albuminuria, is the major cause of end stage renal disease worldwide. Currently albuminuria is considered the best predi...

Mapping interventions addressing frailty and associated outcomes in people with heart failure: a scoping review.

OBJECTIVES: Frailty in people with heart failure (HF) is a multidimensional state and associated with poor outcomes. Addressing frailty in people with HF has been identified as a priority area to impr...

Plasma proteomics improves thrombosis prediction in patients with cancer and identifies targetable IL-17-driven endothelial activation.

Thrombosis remains a major cause of morbidity and mortality in patients with cancer. Existing risk models fail to reliably predict venous thromboembolism (VTE), underscoring the need for more accurate...

Synchronizing brains and hearts: A practical guide for caregiver-child fNIRS-ECG multimodal hyperscanning.

The study of synchrony-concordant neural, physiological, and behavioral activity between individuals-has advanced our understanding of co-regulation and socio-emotional development, particularly withi...

Mechanistic study of annular eccentricity-induced flow instability and thrombus growth in TAVI patients: a geometric sensitivity analysis.

This study investigates the potential hemodynamic penalty of post-TAVI annular eccentricity on thrombogenesis. By integrating patient-specific CTA data with a computational framework coupling multi-co...

Imaging classification of jugular bulb variants on HRCT temporal bone and CT head and neck angiography: prospective study on standardized reporting using lateral skull base landmarks and correlation with condylar vein.

Accurate imaging recognition of jugular bulb (JB) variants is essential for skull-base surgical planning and prevention of intraoperative vascular injury. This prospective study aimed to determine the...

Truncal valve repair combined with right atrial appendage valved right ventricular-to-pulmonary connection in truncus arteriosus type II with single coronary artery.

We present a challenging case of truncus arteriosus type II repair in a 2-month-old, 3.3 kg infant admitted with heart failure and cyanosis. Right ventricular-to-pulmonary arterial continuity was rest...

Damus-Kaye-Stansel procedure in the case of an anteroposterior relationship of great vessels.

This video tutorial demonstrates a Damus-Kaye-Stansel procedure performed concomitantly with a bidirectional cavopulmonary shunt in a patient with a double inlet left ventricle, malposed great arterie...

Clinical spectrum, cardiac phenotypes, and outcomes of FHL1-related cardiomyopathies: a systematic review.

BACKGROUND: Mutations in the Four-and-a-Half LIM Domains 1 (FHL1) gene are increasingly recognized as a rare cause of inherited cardiomyopathies, often associated with skeletal myopathy and adverse ca...

Atrial natriuretic peptide can be biomarker for predicting atrial fibrillation in embolic stroke of undetermined source.

PURPOSE: Atrial fibrillation (AF) drives cardioembolic stroke, yet paroxysmal AF (PAF) often escapes detection in embolic stroke of undetermined source (ESUS). We evaluated whether atrial natriuretic ...

Targeting intracellular cholesterol imbalance rescues sarcomere-ER contact site signaling and ER remodeling in dilated cardiomyopathy.

Dysregulated intracellular lipid metabolism emerged as a driver of heart failure (HF), a leading cause of death worldwide that is frequently caused by dilated cardiomyopathy (DCM). Yet, how defective ...

Postnatal pulmonary artery development from transcript to tissue.

Many congenital conditions and surgical interventions perturb haemodynamics in the proximal pulmonary arteries during postnatal development, thereby altering gene expression and associated changes in ...

Micro-nanoplastics in Cardiovascular Disease: A Critical Update from Environmental Exposure to Clinical Implications.

Micro- and nanoplastics (MNPs) are emerging environmental contaminants that may contribute to cardiovascular risk. Observational human studies have reported the presence of MNPs in patients with myoca...

Investigating the Impact of Continuing Care Model on Quality of Life and Cardiac Function in Patients With Coronary Heart Disease.

AIMS/BACKGROUND: The transition from hospital to home is a critical period for patients with coronary heart disease (CHD), and inadequate post-discharge care can adversely affect recovery. Continuing ...