Association between the C-reactive protein-triglyceride glucose index and coronary collateral circulation in patients with chronic total occlusion: a retrospective study.
OBJECTIVE: To examine the association between the C-reactive protein-triglyceride glucose (CTI) index and coronary collateral circulation (CCC) in patients with chronic total occlusion (CTO), and to a...
Single-point insulin sensitivity estimator and left main and/or three-vessel disease in patients aged 45 years or older with acute coronary syndrome: findings from the CCC-ACS project.
BACKGROUND: Severe coronary anatomical involvement is clinically important in patients with acute coronary syndrome (ACS), yet evidence on its relationship with insulin sensitivity remains limited. Th...
Changes in retinal venous diameter in proliferative diabetic retinopathy patients with diabetic macular edema following faricimab treatment: an observational study.
INTRODUCTION: To evaluate the effect of intravitreal faricimab injections on retinal venous diameter in proliferative diabetic retinopathy (PDR) patients with diabetic macular edema (DME). METHODS: Th...
Uncommon course of the common palmar digital artery of the fourth web space beneath the deep transverse metacarpal ligament: a cadaveric case report.
BACKGROUND: Anatomical variations of the palmar digital arteries are reported less frequently than variations of the superficial and deep palmar arches, particularly regarding their precise topographi...
Association between mental health service utilization and diabetes-hypertension comorbidity: a community-based study.
OBJECTIVE: To examine the association between mental health service (MHS) utilization and diabetes-hypertension (DM-HTN) comorbidity and to explore the roles of depression, health behaviors, and subgr...
A comparative analysis of ACE Inhibitors and ARBs as cancer risk factors.
IMPORTANCE: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely prescribed antihypertensive agents. Although their cardiovascular and renal benefits ar...
HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study.
Atherosclerosis is a chronic inflammatory disease with increasing prevalence in Northeast China, where HLA class II molecules play an important immunoregulatory role. However, the contribution of spec...
HF-OCAQ: Oral comfort assessment in heart failure patients.
Oral discomfort is common among patients with heart failure (HF), with the potential to compromise nutritional intake, communication, and health-related quality of life. Existing oral assessment tools...
Clozapine-Associated Myocarditis with Ventricular Fibrillation Revealing Brugada Syndrome: A Case Report.
Clozapine is the gold-standard treatment for refractory psychotic disorders but is associated with rare, potentially fatal cardiovascular complications. We report the case of a 72-year-old man with sc...
Associations between echocardiographic parameters and aerobic performance in young athletes.
BACKGROUND AND OBJECTIVES: Cardiac morphology can be shaped according to chronic and acute exercise and provides important findings regarding cardiac response to different types of performance. Howeve...
Single-cell and spatial multi-omics reveal estrogen-mediated vaginal wall microenvironment remodeling and a perivascular reparative niche in postmenopausal pelvic organ prolapse.
INTRODUCTION: Local estrogen is widely used to improve vaginal mucosal status and relieve menopausal urogenital symptoms in patients with pelvic organ prolapse (POP), yet clinical outcomes are inconsi...
Progesterone signaling in cardio-renal physiology and pathophysiology.
Progesterone is a multifunctional steroid hormone essential for reproductive function, yet its roles in cardiovascular and renal physiology remain comparatively less understood than those of estrogen....
Radial pulse harmonic analysis for cardiometabolic assessment: a computational and translational mini review.
PURPOSE: Radial pulse harmonic analysis has emerged as a quantitative frequency-domain approach for non-invasive assessment of cardiovascular and metabolic physiology through characterization of arter...
Contractile effects of albiglutide in the human and mouse atrium.
Albiglutide was developed as a glucagon-like-peptide 1 receptor (GLP-1R) agonist for the treatment of type 2 diabetes. We tested the hypothesis that albiglutide exerts a positive inotropic effect in t...
Platelet membrane biomimetic nanoparticle-based targeted delivery system of simvastatin for the treatment of ischemic stroke.
Blood-brain barrier (BBB) disruption and excessive neuroinflammation are pivotal drivers of cerebral ischemia-reperfusion injury. Although simvastatin (SV) possesses potent pleiotropic effects in prom...
Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes.
Type 2 diabetes is associated with small vessels dysfunction. This study assessed whether type 2 diabetes is associated with changes in the myocardial capillary pattern in two-dimensional histological...
Assessment of Impacts of Clinically Effective Antihypertensive Herbal Medicines on the Activities of Major Drug Metabolizing Enzymes and Transport Proteins.
INTRODUCTION: Hypertension is one of the most common non-communicable diseases, and reports indicate that its prevalence is escalating globally due to several factors. Studies in different countries h...
Dihydrotanshinone I Attenuates Atherosclerosis via Inhibiting NLRP3 Inflammasome Activation and Modulating Gut Microbiota.
Atherosclerosis (AS), a primary contributor to cardiovascular disease, is driven by hyperlipidemia, chronic inflammation, and gut dysbiosis. Although Salvia miltiorrhiza Bunge (Danshen) has long been ...
Case Report: Pediatric ACTH-secreting pituitary adenoma presenting with hypertension and anuria.
BACKGROUND: Adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are rare endocrine neoplasms. Pituitary apoplexy, caused by acute hemorrhage or infarction within the tumor, is an uncommon ...
Yangxin Tongluo Decoction Protects Against Sepsis-Associated Cardiac Dysfunction Through Regulating Nrf2 Pathway.
BACKGROUND: Sepsis-induced cardiac dysfunction is a major cause of high mortality in critically ill patients. Yangxin Tongluo decoction (YXTLD), a traditional Chinese medicine (TCM) formula, is clinic...