Image Quality as an Important Confounder in Quantitative OCT Angiography: A Review with Quantitative Synthesis.
BACKGROUND: Optical coherence tomography angiography (OCTA) provides quantitative metrics of the retinal microvasculature, most prominently vessel density (VD), that are increasingly used as biomarker...
MitoQ Has Diverse Effects on H(2)O(2)-Induced Oxidative Stress and the NRF2 Signalling Pathway in Aortic Smooth Muscle Cells of Different Origins.
Oxidative stress plays a central role in the development and progression of abdominal aortic aneurysms (AAA), as it severely impairs the function and survival of vascular smooth muscle cells (VSMCs). ...
NaF-PET Imaging for Detection of Early Arterial Microcalcification and Monitoring of Targeted Therapy: A Narrative Review.
Ischemic heart disease is currently diagnosed mainly through cardiac computed tomography (CT) angiography and functional testing, both of which detect only advanced arterial macrocalcification, at a s...
May-Thurner Syndrome secondary to the oral contraceptive pill.
PRESENTATION: A teenaged female patient presented with left leg pain and swelling for two days. The pain radiated to the left iliac fossa and suprapubic region. DIAGNOSIS: May Thurner Syndrome with ex...
Semi-supervised Omics Factor Analysis (SOFA) disentangles known and latent sources of variation in multi-omic data.
A fundamental design pattern in biomolecular studies is to assay the same set of samples (organisms, tissue biopsies, or individual cells) by multiple different 'omics assays. Group Factor Analysis (G...
Pathogenesis and molecular mechanisms of mutant TIE2-driven venous malformation.
Venous malformation (VM) is the most common subtype of vascular malformation. Due to the chronic nature of this disorder, VM patients face significant morbidity and complications throughout their live...
Antisense oligonucleotide-mediated disruption of mRNA localisation inhibits angiogenesis.
mRNA localisation is a critical posttranscriptional mechanism that confers a spatiotemporal dimension to the control of gene expression. Among diverse outcomes, this process can result in compartmenta...
Feasibility and outcomes of an automated high-alert NT-proBNP pathway.
BACKGROUND: NT-proBNP is a key biomarker in heart failure (HF). Patients with markedly elevated levels are at high risk of adverse outcomes but experience delays in specialist care. Evidence on the im...
Surgically managed paediatric external jugular vein pseudoaneurysm.
Aneurysms and pseudoaneurysms predominantly affect the high-pressure arterial system; venous manifestations are exceedingly rare. While the internal jugular vein is the most common cervical site-typic...
Women in healthy transition deep phenotyping cohort study protocol (KiSO-DP): a within-participant multidisciplinary longitudinal cohort study across the menopausal transition.
BACKGROUND: Cardiovascular disease risk accelerates in women after the menopausal transition, coinciding with the cessation of endogenous oestrogen production. The accompanying decline in vascular fun...
Pathological depositions in human disease: converging mechanisms in atherosclerosis, Alzheimer's disease, and related disorders.
Pathological deposition of endogenous material within tissues represents a central, unifying mechanism across a broad spectrum of prevalent human diseases. Atherosclerosis and Alzheimer's disease (AD)...
Prediction of Atrial Fibrillation Occurrence With Handheld Mobile Electrocardiogram: Deep Learning Model Development Using Real-World Data.
BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia associated with an increased risk of stroke and heart failure. To improve prevention, recent studies have used deep learning models to ident...
Tracing the origins of de novo coronary collateral formation in cardiac repair.
Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble int...
Modality-specific neurovascular coupling via layer-segregated arteriole networks.
The brain's vascular system dynamically regulates energy supply through neurovascular coupling. In this study, we show that in mice, neurovascular coupling is modality-dependent: Distinct sensory inpu...
Targeting ACTG1 alleviates isoproterenol-induced cardiac injury by regulating endothelial-to-mesenchymal transition.
The pathological mechanisms underlying cardiac fibrosis after isoproterenol (ISO)-induced cardiac injury remain poorly understood. Additionally, the biological function of ACTG1 in cardiovascular dise...
Macular perfusion analysis using optical coherence tomography angiography post rhegmatogenous retinal detachment repair: a systematic review and meta-analysis.
BACKGROUND: Evaluating rhegmatogenous retinal detachment (RRD) repair traditionally focuses on anatomical reattachment and visual acuity. Understanding macular perfusion changes post-repair offers a m...
Role of semaphorin 4f in cardiac fibroblasts to regulate matrix production through actin remodeling and YAP/TAZ activation.
Cardiac fibrosis remains a critical determinant of adverse outcomes in heart disease, yet effective anti-fibrotic therapies are lacking. While multiple semaphorin family members participate in cardiov...
APOM-associated inflammation and apoptosis in stroke-exacerbated myocardial infarction: implications for brain-heart interactions.
Brain-heart syndrome (BHS) describes cardiac dysfunction secondary to central nervous system injury, with acute ischemic stroke (AIS) serving as a critical driver that exacerbates myocardial infarctio...
[Perioperative outcomes and anesthetic management of pregnancy termination in patients with pulmonary hypertension].
OBJECTIVES: To investigate outcomes of pregnancy termination in women with pulmonary hypertension (PH) and the correlations of anesthetic management strategies and intraoperative blood pressure variab...
[A semi-supervised MRI image segmentation dual-network model for regions with ambiguous boundaries and heterogeneous regions].
OBJECTIVES: To construct a high-value region-guided dual-network semi-supervised segmentation method (HVASS) under extremely low labeling rates for addressing the challenges of heterogeneity and blurr...