Influencing Factors and Prediction Model Construction of Anxiety and Depression in Patients With Coronary Heart Disease Undergoing In-Stent Restenosis.

BACKGROUND: In-stent Restenosis (ISR) represents a major challenge in interventional cardiology, and psychological distress is known to worsen coronary heart disease outcomes. However, the prevalence ...

An(other) interview with Rashmi Priya.

Rashmi Priya is a Group Leader at The Francis Crick Institute, UK. Rashmi's lab uses advanced microscopic, genetics and biophysical approaches to understand the underlying molecular and cellular mecha...

Inclisiran-induced LDL-cholesterol reduction with and without concomitant statin therapy: a real-world analysis.

Inclisiran lowers LDL-cholesterol (LDL-C) by inhibiting hepatic PCSK9 synthesis. Whether concomitant statin therapy modifies the magnitude of inclisiran-associated LDL-C reduction in routine clinical ...

[Disease burden and risk factors of myocarditis among children and adolescents aged 0-19 years in China from 1990 to 2021 and projection of future disease burden trends].

OBJECTIVES: Based on data from the Global Burden of Disease Study (GBD) 2021, this study aims to analyze trends in myocarditis among children and adolescents aged 0-19 years in China from 1990 to 2021...

[Screening and genetic variation analysis of fatty acid oxidation disorder in neonates in Qingdao City].

OBJECTIVES: To investigate the incidence, genetic mutation characteristics, and prognosis of fatty acid oxidation disorder (FAOD) in neonates in Qingdao. METHODS: Clinical data of neonates diagnosed w...

Effect of tirzepatide and semaglutide on blood pressure: A systematic review and meta-analysis.

PURPOSE: Tirzepatide and semaglutide are widely used for type 2 diabetes mellitus (T2DM) and obesity. However, the blood pressure-related adverse event profiles associated with tirzepatide and semaglu...

Neuro-images: "string of beads" at vertebral artery origin: 3-year angiographic follow-up after stenting for fibromuscular dysplasia.

Fibromuscular dysplasia (FMD) rarely involves the vertebral artery origin (V1 segment), a site far more commonly affected by atherosclerosis. We report an 81-year-old woman with recurrent, medically r...

PKA-Mediated Proteasome Activation Protects Against Cardiac Remodeling and Heart Failure During Systolic Overload.

Heart failure (HF) resulting from chronic systolic overload is associated with increased burden on proteostasis and impaired proteasome function. Phosphorylation of proteasome subunit RPN6/PSMD11 at S...

ZHX2 Alleviates Vascular Remodeling and Smooth Muscle Cell Proliferation by Transcriptional Regulation of GADD45G.

Based on findings from human atherosclerotic arteries and mouse arterial injury models, where ZHX2 expression is significantly downregulated, this study identifies ZHX2 as a critical inhibitor of path...

Ninjurin2 Promotes Pulmonary Endothelial Barrier Dysfunction Through VEGF/VEGFR2 Signaling Pathway.

Previous studies have established an association between Ninjurin2 and diseases related to vascular endothelial dysfunction, such as ischemic stroke and coronary heart disease. Given that impaired pul...

WTAP Histone Lactylation Drives the YTHDF1/ALOX15 Axis to Regulate Ferroptosis in Myocardial Ischemia-Reperfusion Injury.

Lactate, a metabolic byproduct of glycolysis, accumulates during myocardial infarction and ischemia/reperfusion (I/R) injury, acting as both a metabolic stress marker and a signaling molecule that inf...

Nuclear m6A Methylase METTL3 Drives Production of ITGβ4E to Exacerbate Heart Failure via SRSF3-Mediated Alternative Splicing of ITGβ4.

Heart failure (HF) is an important cause of morbidity and mortality worldwide. Here, we aimed to screen potent regulators in HF progression to assist clinicians in the early diagnosis and management o...

Intracoronary imaging (ICI) is an important adjunct to invasive coronary angiography for the assessment of lesion morphology and guidance of percutaneous coronary intervention (PCI). Extensive data, i...

Lipoprotein(a) and Hypertension-Mediated Organ Damage in Patients with Essential Hypertension: Associations with Carotid Plaque and Impaired Nocturnal Blood Pressure Dipping.

Background and Objectives: Lipoprotein(a) [Lp(a)] is an established cardiovascular risk factor associated with atherosclerosis, vascular inflammation, and endothelial dysfunction. However, data regard...

Association Between Maternal Angiogenic Markers in Hypertensive Disorders of Pregnancy and Neonatal Growth and Body Composition.

Background/Objectives: Hypertensive disorders of pregnancy (HDPs) such as preeclampsia are associated with adverse maternal and perinatal outcomes and related to high soluble fms-like tyrosine kinase-...

Mechanistic Insights into the Antihypertensive and Cardioprotective Actions of Corosolic Acid: A Narrative Review.

BACKGROUND: The specific mechanisms underlying the antihypertensive actions of corosolic acid (CA) have not been systematically elucidated. METHODS: Evidence was categorized according to major signali...

Visceral Adiposity Is Independently Associated with Hypertension in Thai Adults: A Case-Control Study.

BACKGROUND: Hypertension is a major public health challenge and a leading contributor to cardiovascular morbidity and mortality worldwide. Although obesity is a well-established risk factor for hypert...

Association Between Baseline Soluble ST2 Levels and Long-Term Outcomes After Percutaneous Coronary Intervention.

Background and Objectives: Soluble suppression of tumorigenicity-2 (sST2) is a biomarker associated with myocardial stress, inflammation, and fibrosis. Although elevated sST2 levels have demonstrated ...

Association of PON1 Haplotypes (Q192R and L55M) with the Severity of Coronary Atherosclerosis.

Enzyme paraoxonase 1 (PON1) plays a protective role against atherosclerosis by preventing the oxidation of low-density lipoproteins (LDL). Polymorphisms in the PON1, particularly Q192R and L55M, have ...

The Role of Endothelial Dysfunction in Fracture Healing: Mechanisms and Potential Effects on Skeletal Repair.

Fracture healing depends on coordinated osteogenesis and restoration of the vascular microenvironment. Endothelial cells support skeletal repair through angiogenesis, tissue perfusion and angiocrine s...