Association and Risk-Stratification Value of the Positive Remodeling Index of Middle Cerebral Artery Atherosclerotic Plaques for Perforator-Territory Infarction Based on High-Resolution Magnetic Resonance Imaging.

BACKGROUND: Atherosclerosis of the middle cerebral artery (MCA) is a major contributor to ischemic stroke, and infarcts confined to the perforator territory can produce considerable neurological dysfu...

Effects of ursodeoxycholic acid on statin-induced impaired glucose tolerance: study protocol for a randomized controlled trial.

INTRODUCTION: Statin therapy is associated with an increased risk of dysglycaemia and new-onset type 2 diabetes, which compromises patient adherence. Ursodeoxycholic acid (UDCA), a hepatoprotective dr...

Care Partner Perspectives on Hypertension Management in Alzheimer Disease and Related Dementias in an Online Forum: Qualitative Thematic Analysis.

BACKGROUND: Family care partners manage care for individuals with Alzheimer disease and related dementias (ADRD), including hypertension management crucial for preventing cognitive decline. Nurses fre...

Pre-IVIG echocardiography enables targeted treatment in infants younger than 6 months with Kawasaki Disease : Echocardiography-based risk stratification in young infants with Kawasaki Disease.

UNLABELLED: The 2024 American Heart Association scientific statement suggests intensification therapy in infants younger than 6 months (< 6 months) with Kawasaki disease (KD) may be beneficial, but in...

The ManageHF Just-in-Time Adaptive Mobile App Interventions to Promote Self-Management and Improve Outcomes in Heart Failure: Randomized Controlled Trial.

BACKGROUND: Heart failure (HF) is a major health care challenge in the United States, with approximately 900,000 older adults hospitalized annually. Gaps in self-management, including unrecognized wor...

FOSL2 Regulates PANoptosis in Cardiomyocytes and Heart Failure Progression After Acute Myocardial Infarction by Promoting NLRP12.

NLRP12 can induce PANoptosis, a novel form of inflammatory cell death. The research aimed to investigate the mechanisms of NLRP12 in regulating PANoptosis during postinfarction heart failure (HF). C57...

Diffuse hemispheric glioma, H3 G34-mutant, in Simpson-Golabi-Behmel syndrome: the first reported case.

Simpson-Golabi-Behmel syndrome (SGBS) is an overgrowth syndrome associated with an increased risk of certain malignancies; however, gliomas have not previously been reported in patients with SGBS. Los...

Identification of pulmonary hypertension with pulmonary vascular surface volume ratio by non-contrast CT.

BACKGROUND: The diagnosis of pulmonary hypertension (PH) relies primarily on invasive right heart catheterization (RHC). Although imaging modalities, including echocardiography, computed tomography an...

Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events.

BACKGROUND: Data on the prognostic value of incidental coronary artery calcium (CAC) from nongated chest computed tomography scans are limited. Using paired computed tomography scans from the MESA (Mu...

Classification models for KCNQ1 variants distinguish functional and trafficking effects to enhance pathogenicity interpretation.

Missense variants in the potassium channel KCNQ1 underlie most cases of congenital long QT syndrome (LQTS), one of the most common genetic arrhythmias. Variants affect protein stability, trafficking, ...

Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study.

BACKGROUND AND OBJECTIVES: Genetics represent a nonmodifiable risk factor for Alzheimer disease (AD), with 60%-80% heritability. Midlife hypertension is a modifiable risk factor for both dementia and ...

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

BACKGROUND AND OBJECTIVES: In acute ischemic stroke with large vessel occlusion (AIS-LVO), interhospital transfer for endovascular therapy (EVT) provides an ideal therapeutic window during which neuro...

Cerebral Artery Pulsatility, Premorbid Blood Pressure, and Small Vessel Disease on Brain Imaging: A Population-Based Study.

BACKGROUND AND OBJECTIVES: Increased pulsatility of cerebral blood flow is proposed as a potential cause of cerebral small vessel disease (SVD), but the apparent association could be confounded by sha...

Influence of Surgical Timing on the Risk of Permanent Pacemaker Implantation in Acute Aortic Valve Endocarditis.

Background and Objectives: The optimal timing for surgical intervention in acute aortic valve infective endocarditis (IE) remains debated. Although European guidelines distinguish emergency, urgent, a...

Inter-Observer Reliability in Myocardial Blood Flow Measurement Using Rb-82-PET/CT.

Background/Objectives: Myocardial perfusion PET/CT, e.g., using Rb-82, enables the measurement of absolute myocardial blood flow (MBF) and, hence, the blood flow reserve, which plays a crucial role in...

Prevalence and Determinants of Poor Sleep Quality Among Patients with Established Coronary Heart Disease in Kazakhstan: A Multi-Center Cross-Sectional Study.

BACKGROUND: Poor sleep quality is an increasingly recognized, modifiable cardiovascular risk factor, yet data among patients with established coronary heart disease (CHD) in Central Asia are scarce. W...

Low-density lipoprotein cholesterol is inversely associated with left atrial low-voltage areas in patients with persistent atrial fibrillation: a retrospective cohort study.

BACKGROUND: Left atrial low-voltage areas (LVAs) reflect advanced atrial remodeling and are associated with postablation recurrence in patients with persistent atrial fibrillation (PerAF). However, th...

Intestinal Flora and Myocarditis: Potential Mechanisms and Therapeutic Strategies Affecting Disease Progression and Cardiac Function.

Myocarditis is a clinically challenging form of inflammatory heart disease with heterogeneous etiologies, limited diagnostic tools, no targeted therapies, and a substantial risk of progression to hear...

The Redox-Inflammation Axis in Atherosclerosis and Ischemic Stroke: Mechanisms, Biomarkers, and Translational Challenges.

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and are driven by the interplay between oxidative stress and chronic inflammation. Although these processes have been ext...

The Association Between Matrix Metalloproteinase-1, -2, -3, -9, and -12 Gene Polymorphisms and Atrial Fibrillation.

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with significant morbidity and mortality. Structural remodeling of the left atrium, particularly myocardial fibrosis, plays a key ...