Imaging-Based Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy: Current Evidence and Clinical Perspectives.
Hypertrophic cardiomyopathy (HCM) is a common inherited myocardial disorder and a leading cause of sudden cardiac death (SCD) across all age groups. Accurate risk stratification remains a clinical cha...
Chronic Infection and Cardiac Aging: a New Perspective on Pathogen-Associated Cardiomyopathy.
Cardiovascular diseases remain the primary driver of global mortality, with advanced age serving the most significant risk factor for their development and progression. Emerging evidence suggests that...
Reliability and device objectivity in oscillatory blood pressure measurement - a measurement error analysis to inform clinical decision making.
The implementation of different hypertension thresholds (e.g. ESC/ESH: 140:90 or ACC/AHH: 130:80) substantially increased hypertension prevalence donation of pharmacological treatment across various p...
Single-Dose Nivolumab as a Trigger of Myocarditis, Myositis, and Myasthenia Gravis Overlap Syndrome With Late Cardiac Death Despite Initial Recovery: A Case Report.
BACKGROUND Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced malignancies but can cause life-threatening immune-related adverse events. Myocarditis, myositis, and myasthen...
Blood pressure management in reperfused ischemic stroke.
RATIONALE: Stroke is the second leading cause of death worldwide and a major contributor to disability, with ischemic strokes accounting for 80% to 85% of all strokes. Appropriate blood pressure manag...
Chronic Pruritus in Predialysis Chronic Kidney Disease: Prevalence, Phenotype and Temporal Patterns in a Prospective Cohort.
CKD-associated pruritus (CKD-aP) is a burden some symptom with incompletely understood pathophysiology and limited predialysis data. In this prospective observational study, 95 adult nondialysis CKD p...
Association Between Total Cholesterol-to-High-Density Lipoprotein Ratio and Gestational Hypertension: A Case-Control Study.
BACKGROUND While dyslipidemia has been implicated in gestational hypertension (GH), individual lipid parameters show inconsistent associations. The total cholesterol to high-density lipoprotein choles...
Impact of carvedilol versus metoprolol on ventricular arrhythmia burden and ICD therapies: a systematic review and meta-analysis.
BACKGROUND: Ventricular arrhythmias (VA) are major causes of morbidity and mortality in patients with cardiovascular disease. Implantable cardioverter-defibrillators (ICDs) are commonly used to preven...
ALPK3 regulates cardiomyocyte apoptosis through the Notch1 signaling pathway.
ALPK3, a gene associated with pediatric cardiomyopathy, plays a pivotal role in cardiac development, yet the regulatory mechanisms governing its involvement in cardiomyocyte apoptosis are still not we...
RBM20 variants disrupt Ca(2+) handling and metabolism in dilated and non-compaction cardiomyopathy stem cell models.
Mutations in the splice-regulator RBM20 cause heart failure with reduced ejection fraction (HFrEF), typically manifesting as dilated cardiomyopathy (DCM). Mutations at position 634 in the RS-domain ca...
Transforming Pulmonary Arterial Hypertension: Key Milestones and Future Perspectives.
Pulmonary arterial hypertension (PAH) is a rare, progressive disease of the precapillary pulmonary arteries, characterized by fibroproliferative vascular remodeling, increased pulmonary vascular resis...
Interleukin-6 is critical in the development of pulmonary vascular disease in Gcn2-deficient mice.
Biallelic mutations in EIF2AK4, encoding Eukaryotic Translation Initiation Factor 2α kinase 4 or General Control Nonderepressible 2 (GCN2), cause pulmonary veno-occlusive disease (PVOD), a fatal form ...
Long-Term Outcomes After Ischemic Stroke Across Atrial Fibrillation Phenotypes Defined by Detection Timing and Prior Anticoagulation Status.
BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF)-associated ischemic stroke is often managed as a single clinical entity; however, prognosis may vary depending on whether AF was detected after the ...
Race and Ethnicity, Hypertension, and Neuroimaging Markers of Brain Aging: A Causal Mediation Analysis in the HABS-HD Study.
BACKGROUND AND OBJECTIVES: The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing the...
This 2025 report from the ESC Atlas project is the fifth in a biennial series. It presents and compares updated cardiovascular disease (CVD) statistics for more than 50 of the ESC member countries. Th...
Cardiovascular disease in China: epidemiological evolution and implications.
Cardiovascular disease (CVD) has remained a predominant cause of mortality in China for several decades, experiencing notable epidemiological transitions. Numerous recent studies have provided valuabl...
Bisphenol F (BPF) is a common substitute for bisphenol A and the most prevalent bisphenol compound in diverse plastic manufacturing applications. However, the potential toxicity of BPF remains largely...
Non-HDL Cholesterol as a Practical Gatekeeper for Adolescent Dyslipidemia Screening: Implications for Nutrition and Public Health.
Dyslipidemia in adolescents represents an early and potentially modifiable stage in the lifelong trajectory of cardiovascular disease. However, optimal lipid screening strategies in this age group rem...
Octacosanol: A Natural Bioactive Ingredient for Atherosclerosis Prevention and Cardiovascular Health Promotion.
Cardiovascular diseases remain the top cause of death worldwide, with atherosclerosis as a key underlying factor. Natural bioactive ingredients from functional foods are increasingly sought after for ...
Multi-Omics and Experimental Validation Reveal the Protective Effect of Paeoniflorin Against Coronary Heart Disease in Mice via Inhibiting the C3-Cfd-C3aR Pathway.
Coronary heart disease (CHD) is a global cardiovascular disease with high morbidity and mortality, and its complex pathological mechanism poses great challenges to clinical prevention and treatment. P...