Targeting Endothelial PDK4-EndoMT Feedback Loop Mitigates the Development of Thoracic Aortic Dissection in Mice
Xiangyu Cao (Kumamoto University/日本), Xingyou Guo (Tokai University/日本), Haoyue Huang (Juntendo University/日本), Han Shen (University of Tokyo/日本), Jingze Zhu 等14人
📖 Arteriosclerosis, Thrombosis, and Vascular Biology
📅 2026-03-19
thoracic aortic dissection
endothelial-to-mesenchymal transition
PDK4
SNAI1
vascular integrity
dichloroacetate
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Angiotensinogen Reconsidered: Evolving Perspectives in Hypertension Research
Mehmet Kanbay (The Ohio State University Wexner Medical Center/美国), Mustafa Guldan, Lale Ozbek, Randa Al-Shiab, Linda J Laffin
📖 Hypertension
📅 2026-03-19
angiotensinogen
hypertension
inflammation
obesity
RNA therapeutics
zilebesiran
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Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial
Yan Shen (Samsung Medical Center/韩国), Chenxi Zeng (Asan Medical Center/韩国), Yan Sun (Severance Hospital/韩国), Jing Wang (Chonnam National University/韩国), Bo Yu 等59人
📖 Circulation
📅 2026-03-19
premature atrial contractions
memantine
NMDA receptor
arrhythmia
atrial fibrillation
randomized clinical trial
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Development and Validation of the AI-HeartAge Model in Framingham and UK Biobank
Timothy J Korzinski (Sahlgrenska University Hospital/瑞典), Benjamin R Prescott (University of Gothenburg/瑞典), David J Hamel-Sellman (Karolinska Institute/瑞典), Vasanthi Xanthakis (Oslo University Hospital/挪威), Lucas L Cooper 等10人
📖 Hypertension
📅 2026-03-19
artificial intelligence
heart age
arterial pressure waveform
heart failure
cardiovascular risk
machine learning
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Hypertriglyceridemia Does Not Worsen Thoracic Aortic Aneurysm and Dissection in GPIHBP1 Knockout Mice
Banglong Wang (Fremantle Hospital/澳大利亚), Zikuan Meng (University of Western Australia/澳大利亚), Jingjing Li (Sir Charles Gairdner Hospital/澳大利亚), Feng Wu, Bin Song 等7人
📖 Arteriosclerosis, Thrombosis, and Vascular Biology
📅 2026-03-19
hypertriglyceridemia
thoracic aortic aneurysm
aortic dissection
GPIHBP1
lipoprotein lipase
extracellular matrix
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Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation.
Paula G Socuéllamos (Instituto de Investigaciones Biomédicas Sols-Morre/Spain), Álvaro Macías (Centro Nacional de Investigaciones Cardiovasculare/Spain), Ángela de Benito-Bueno (Instituto de Investigaciones Biomédicas Sols-Morre/Spain), Francisco M Cruz (Centro Nacional de Investigaciones Cardiovasculare/Spain), María Redondo-Moya (Instituto de Investigaciones Biomédicas Sols-Morre/Spain) 等16人
📖 Cardiovasc Res
📅 2026-03-19
I Kur
Atrial fibrillation
KV1.5 channelosome
Lgi proteins
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