Mechanistic Insights Into the Association Between Gut Microbiota Diversity and Atherosclerosis, Acute Coronary Syndrome, and Peripheral Arterial Disease Progression.

BACKGROUND: The gut microbiome has emerged as a potential contributor to cardiovascular diseases (CVDs), including atherosclerosis, acute coronary syndrome (ACS), and peripheral arterial disease (PAD)...

The Cox-Aalen Rate Model for Recurrent Events With an Informative Terminal Event.

Recurrent event data arise frequently in many clinical and observational studies. In this article, we propose a Cox-Aalen rate model to analyze recurrent event data with a terminal event, where the co...

[Care pathway for the diagnosis and management of patients with hypertrophic phenotype in the Marche Region: the experience of the Marche Cardiomyopathies Network].

BACKGROUND: The aim of this study was to describe the clinical care pathway and results of the first 6 years of activity of the Marche Cardiomyopathy Network (MCN) dedicated to cardiomyopathies with a...

[Myocardial revascularization in patients with heart failure with reduced ejection fraction and ischemic heart disease].

Heart failure with reduced ejection fraction (HFrEF) of ischemic origin represents one of the leading causes of morbidity and mortality and is associated with a poor prognosis. Myocardial revasculariz...

[Feasibility and outcomes of a structured doctor-nurse follow-up program following hospitalization for myocardial infarction or heart failure: the Phase 1 of the DIMACC Project].

BACKGROUND: The year following hospitalization for acute myocardial infarction (AMI) or acute heart failure (AHF) is associated with a high risk of rehospitalization and death, often related to inadeq...

[The trajectory of several cardiovascular drugs: rise, decline, and new therapeutic perspectives].

Cardiovascular pharmacology over recent decades has been characterized by a dynamic and non-linear evolution, in which the introduction of new drugs has often been followed by progressive critical rea...

Withholding Oral Anticoagulation at Discharge and Post-Discharge Stroke and Bleeding Vulnerability in a Predominantly Older Cohort Hospitalized With Acute Heart Failure and Atrial Fibrillation.

AIM: In older adults hospitalized with acute heart failure and atrial fibrillation, bleeding concern often drives withholding of oral anticoagulation at discharge. Whether withholding marks a genuinel...

[Ventricular hypertrophy and pre-excitation: a diagnostic clue to PRKAG2-related cardiomyopathy].

PRKAG2-related cardiomyopathy is a metabolic phenocopy of hypertrophic cardiomyopathy characterized by ventricular hypertrophy, pre-excitation, and supraventricular arrhythmias, frequently leading to ...

Early Cardiotoxic Remodelling Precedes Hepatic Fibrosis and Increases Susceptibility to Lethal Arrhythmias in Wild-Type MASH Mice.

OBJECTIVE: Metabolic dysfunction-associated steatohepatitis (MASH) is increasingly linked to cardiovascular complications; however, the mechanisms underlying the association between hepatic injury and...

Dosimetric impact of aperture-restricted VMAT on heart dose in breast cancer treated with regional nodal irradiation.

BACKGROUND: Volumetric modulated arc therapy (VMAT) is increasingly used for breast and chest wall (CW) treatment with regional nodal irradiation (RNI) because of its ability to sculpt dose around com...

[A case of percutaneous closure of a complex coronary artery fistula].

Coronary artery fistulas (CAFs) are rare coronary anomalies defined as abnormal direct communications between a coronary artery and a cardiac chamber or great vessel. We report the case of a 66-year-o...

[Interarterial anomalous right coronary artery in a competitive athlete: case report].

Anomalous origin of the right coronary artery from the left sinus of Valsalva with an interarterial course is a congenital coronary anomaly associated with myocardial ischemia and sudden cardiac death...

Diagnostic Value of 3D Transesophageal Vena Contracta Area versus 2D Echocardiographic Assessment of Secondary Mitral Regurgitation.

BACKGROUND: Secondary mitral regurgitation (MR) is associated with substantial cardiovascular morbidity and mortality, making accurate severity assessment essential for clinical management. Convention...

A Rare Vascular Tangle Unraveled: Multimodal Imaging in Giant Coronary Arteriovenous Fistula.

A 63-year-old woman presented with intermittent palpitations. Transoesophageal echocardiography (TEE) identified a high-velocity shunt from a tortuous left circumflex artery into an enlarged coronary ...

Portal Vein Thrombosis Risk in Cirrhotic Patients With Portal Hypertension on Beta-Blockers: A Multi-Institutional Cohort Study.

BACKGROUND: Portal vein thrombosis (PVT) is a significant complication of cirrhosis. Nonselective beta-blockers (NSBBs) are standard therapy for portal hypertension, but their effect on PVT risk remai...

Aging-Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin-Related Protein 1-Associated Mitochondrial Vulnerability.

Chronic intermittent hypoxia (CIH), a cardinal pathophysiological feature of obstructive sleep apnea (OSA), repeatedly exposes the heart to hypoxia-reoxygenation stress. The cardiac outcome of CIH, ho...

Left Ventricular Global Longitudinal Strain as a Marker of Subclinical Myocardial Dysfunction in Youths With Type 1 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis.

AIMS: To assess Left Ventricular Global Longitudinal Strain (LV GLS) in youths with type 1 diabetes mellitus (T1DM) compared with healthy controls, as a marker of subclinical myocardial dysfunction. M...

Does Intravenous Iron Improve Survival and Physical Function and Reduce Heart Failure Events in Patients with Chronic Kidney Disease?

AbstractIron deficiency is common in patients with chronic kidney disease (CKD). Contemporary guidelines recommend the use of iron therapy only in the presence of anemia. However, patients with CKD ar...

Gamified Cardiopulmonary Rehabilitation in a Child Undergoing LVAD Bridging Therapy to Heart Transplantation: A Case Report.

This report details the comprehensive, gamified cardiopulmonary rehabilitation of a 6-year-old girl undergoing a complex clinical journey from left ventricular assist device (LVAD) bridge therapy to s...

The Value of Left Atrial Strain and Strain Rate for Prediction of Early Postoperative Atrial Fibrillation Following Isolated Off-Pump Coronary Artery Bypass Grafting in Low-Risk Patients.

BACKGROUND: Following coronary artery bypass grafting (CABG) surgery, postoperative atrial fibrillation (POAF) is a prevalent arrhythmia. Prior research has demonstrated a paucity of reliable approach...