Inferior Vena Cava Ultrasound for Decongestion Assessment in Acute Heart Failure: Systematic Review.
BACKGROUND: Residual congestion at discharge in acute heart failure (AHF) is a primary driver of readmission and mortality. Inferior vena cava (IVC) ultrasound provides a noninvasive bedside assessmen...
Ethanol Infusion Into the Vein of Marshall for Atrial Fibrillation: Clinical Efficacy and Technical Limitations.
BACKGROUND: Despite advancements in radiofrequency ablation (RFCA) technology and strategy, the long-term rhythm outcomes of persistent atrial fibrillation (PeAF) remain suboptimal. Since the vein of ...
Carbon Dioxide Concentration Alters the Dynamics of Oxygen-Mediated Capillary Blood Flow Responses in Skeletal Muscle.
HYPOTHESIS: We hypothesize that the dynamics of O2-mediated blood flow responses in skeletal muscle capillaries are altered under different tissue carbon dioxide concentrations ([CO2]) due to the inte...
Diabetes Upregulates BK(Ca) Channels in Pulmonary Arterial Smooth Muscle by Altering the Local Control Mechanism of the Pore-Gate Domain.
OBJECTIVE: Large conductance calcium-activated potassium channels (BKCa) play an important role in the regulation of vascular tone. However, the properties of BKCa channels in smooth muscle of pulmona...
Impact of prenatal maternal LDH levels on adverse pregnancy outcomes in women with hypertensive disorders during pregnancy.
OBJECTIVE: This study aimed to evaluate the association between maternal serum lactate dehydrogenase (LDH) levels and adverse pregnancy outcomes in women with hypertensive disorders of pregnancy (HDP)...
Multi-Center Adversarial Bi-Phase Cross-Attention Network for Right Ventricular Segmentation and Functional Classification in Echocardiography.
BACKGROUND: Automated right ventricular (RV) analysis in 2D echocardiography is limited by the morphological complexity of RV segmentation and the domain fragility of single-center deep learning model...
Uterine artery pseudoaneurysm: Rare cause of delayed postpartum hemorrhage.
OBJECTIVE: To identify a rare but potentially life-threatening cause of delayed postpartum hemorrhage. CASE REPORT: A 36-year-old woman, gravida 1, para 1, had just underwent cesarean section at a loc...
DRIVE v3: Command Line Application for Identity-by-Descent Haplotype Clustering in Large Biobank Scale Data.
There is a need for genetic analytical methods that integrate multi-individual identity-by-descent (IBD) tools with phenotypic enrichment testing to discover novel shared haplotypes contributing to di...
Synergistic Cardioprotection of Colchicine and Hyperbaric Oxygen Therapy in a Rat Model of Remote Ischemia-Reperfusion Injury.
PURPOSE: Lower extremity ischemia-reperfusion injury (IRI) triggers systemic inflammation and oxidative stress, causing myocardial remote ischemia-reperfusion injury (MIRI). Current treatments are lim...
Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND.
INTRODUCTION: Whether cardiovascular-kidney-metabolic (CKM) syndrome stage modifies cognitive benefits of intensive blood pressure (BP) control remains unclear. METHODS: This post hoc analysis of Sys...
Inpatient Outcomes and Complications After Left Atrial Appendage Occlusion in Rural Versus Urban Hospitals in the United States.
BACKGROUND: Disparities in management of atrial fibrillation in rural and urban hospitals across the U.S. have been reported. However, studies investigating disparities regarding outcomes and complica...
Clinical analysis of postmenopausal women with intravenous leiomyomatosis.
OBJECTIVE: Intravenous leiomyomatosis is a rare disease that occurs in premenopausal women. We examined the clinical characteristics, diagnosis, and therapeutic approaches of intravenous leiomyomatosi...
Cerebral arteries segmentation based on projection domain in single exposure computed tomographic angiography.
BACKGROUND: Cerebrovascular diseases are major causes of death and disability worldwide, highlighting the critical importance of early diagnosis and accurate acquisition of vascular information. Howev...
[Bempedoic acid in real-world clinical practice: baseline and 8-week data from the Italian prospective, non-interventional MILOS study].
BACKGROUND: Bempedoic acid (BA), an adenosine triphosphate-citrate lyase inhibitor, effectively reduces LDL cholesterol (LDL-C) and cardiovascular (CV) risk, as demonstrated in randomized clinical tri...
Empowering Patients with Heart Failure Through Health Coaching: A Quasi-Experimental Study.
BACKGROUND: Chronic heart failure (CHF) is a complex and often progressive condition, requiring ongoing self-management and lifestyle adjustments. Empowerment, which refers to a person's ability to ov...
[Ranolazine: established indications and emerging therapeutic potential].
Ranolazine, approved for the symptomatic treatment of chronic stable angina, is currently indicated as an additional treatment when angina symptoms are not controlled with traditional drugs such as be...
[The application of artificial intelligence in arrhythmology].
In recent decades, clinical practice has been founded on the principles of evidence-based medicine, where therapeutic decisions arise from the integration of clinical expertise, patient preferences, a...
Long-Term Safety and Renal Outcomes of Semaglutide in Non-Diabetic Obesity with Chronic Kidney Disease or Hypertension: A Systematic Review and Meta-Analysis.
BACKGROUND: Semaglutide, a GLP-1 receptor agonist, has demonstrated metabolic and renal benefits in diabetic populations. However, its efficacy and safety in non-diabetic individuals with obesity and ...
Sociodemographic determinants of Pulmonary Hypertension in a Tertiary Care Hospital in Southern India.
BACKGROUND: Pulmonary hypertension (PH) is a progressive disorder with significant morbidity and mortality. Limited data exist on the demographics, echocardiographic profile, and quality of life of PH...
A Multi-Stage Drop-the-Loser Design With Superiority Boundaries.
Multi-arm multi-stage (MAMS) trials have gained popularity, due to their improved efficiency in evaluating multiple treatments. A traditional MAMS trial often decreases the expected sample size of the...