A novel LepR knockout hamster model for type 2 diabetes and its complications: a complementary platform to conventional rodent models.

BACKGROUND: Type 2 diabetes (T2D) is a progressive metabolic disorder characterized by systemic metabolic dysfunction and multi-organ complications that considerably increase morbidity and mortality. ...

Metabolic, inflammatory, and lipoprotein(a)-related risk profiling for incident ASCVD: a multi-biomarker study.

AIMS: Metabolic dysfunction, inflammation, and lipoprotein(a) [Lp(a)] reflect different biomarker domains associated with atherosclerotic cardiovascular disease (ASCVD) risk. We examined the individua...

Early relative glycemic stress trajectories identify a high-risk metabolic phenotype in critically ill patients with atherosclerotic cardiovascular disease: a dual-cohort study.

BACKGROUND: The stress hyperglycemia ratio (SHR) captures acute glucose elevation relative to chronic glycemic background. However, the prognostic value of early dynamic SHR patterns in critically ill...

Geriatric syndromes and intrinsic capacity in older adults with coronary heart disease: a cross-sectional study in China.

BACKGROUND: Geriatric syndromes (GS) are highly prevalent among community-dwelling older adults with self-reported physician-diagnosed coronary heart disease (CHD), but their association with intrinsi...

Uncovering Potential Druggable Targets in Coronary Atherosclerosis: A Proteome-Wide Mendelian Randomization Study With Cross-Platform and Experimental Validation.

BACKGROUND: Coronary atherosclerosis (CA) is a leading cause of cardiovascular morbidity and mortality worldwide. This study is aimed at identifying candidate plasma proteins and potential therapeutic...

Evolocumab in the treatment of refractory chylothorax induced by systemic lupus erythematosus complicated with hyperlipidemia: a case report and literature review.

Recurrent chylothorax induced by thoracic duct injury in patients complicated with mixed hyperlipidemia secondary to systemic lupus erythematosus (SLE) is rarely encountered in clinical practice. A 55...

Identification of novel peripherally restricted risperidone-like dopamine D2 receptor antagonists for prolactin-mediated neuroprotection through a multi-stage in silico screening.

Prolactin, a hormone with emerging neuroprotective roles, has demonstrated potential in mitigating cognitive impairment under specific neurotoxic conditions, including environmental toxicity and excit...

Aortic valve repair in 2026 - state of the art: what every cardiologist should know.

Aortic valve repair (AVr) has evolved into a reproducible surgical strategy for selected patients with aortic regurgitation (AR), offering preservation of native tissue, avoidance of prosthesis-relate...

Nailfold capillaroscopy in diabetic retinopathy: microvascular insights, clinical value, and translational challenges - a narrative review.

Diabetic retinopathy (DR) is a leading microvascular complication of diabetes mellitus and a major cause of preventable vision loss. DR is now viewed as a manifestation of systemic diabetic microangio...

Obstetric conditions requiring intensive care at the Analankininina University Hospital Centre, Toamasina, Madagascar.

The management of obstetric emergencies in the intensive care unit (ICU) requires a multidisciplinary approach. This study aimed to describe the epidemiological and clinical profiles of obstetric pati...

Cognitive impairment and associated factors among community-dwelling older adults with hypertension in tropical China.

BACKGROUND: Cognitive impairment (CI) is highly prevalent among older adults with hypertension and imposes substantial burdens on individuals, families, and healthcare systems. Identifying factors ass...

Health-seeking behaviors of pregnant women with hypertensive disorders of pregnancy in low- and middle-income countries: A scoping review protocol.

Hypertensive disorders of pregnancy (HDP) are among the leading causes of maternal and perinatal illness and death worldwide. Despite advances in its management, the burden of HDP remains disproportio...

Assessment of predictive factors for acute kidney injury after thrombectomy using AngioJet for iliofemoral deep vein thrombosis.

OBJECTIVE: To identify the relationship between acute kidney injury (AKI) and the treatment of iliofemoral deep vein thrombosis in the acute phase using an AngioJet® device. METHODS: This retrospectiv...

Dual Therapy vs. Single Anticoagulation After Acute Deep Vein Thrombosis Iliac Stenting: A Doubly Robust Multicenter Study.

BackgroundThe optimal antithrombotic strategy after iliac vein stenting for acute iliofemoral deep vein thrombosis (IFDVT) remains uncertain. We compared dual antithrombotic therapy (DAT) with single ...

Artificial intelligence-integrated multimodal retinal imaging for early detection and risk stratification of systemic vascular and neurodegenerative diseases.

BACKGROUND: We developed and validated RetinalVNG-Net, a multimodal deep learning framework for simultaneous risk stratification of hypertensive retinopathy, diabetic retinopathy, and neurodegenerativ...

Molecular basis of coronary artery disease-malignancy comorbidity: inflammation, immunometabolism, thrombosis, and cardio-oncology translation.

Coronary artery disease (CAD) and malignancy frequently coexist in aging populations and share multiple risk factors, including smoking, obesity, diabetes, dyslipidemia, chronic inflammation, and meta...

The metabolic-inflammatory axis in chronic heart failure: integrating the NLR and TyG index for recent-onset atrial fibrillation prediction via machine learning and mediation analysis.

INTRODUCTION: Recent-onset atrial fibrillation (AF) is a common complication of chronic heart failure (CHF), potentially involving both inflammatory and metabolic dysregulation. This study aimed to de...

Rg1-Loaded Tetrahedral DNA Nanostructures Attenuate Myocardial Ischemia-Reperfusion Injury by Suppressing Oxidative and Endoplasmic Reticulum Stress.

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) remains a major clinical challenge in the management of acute myocardial infarction. Ginsenoside Rg1, a bioactive component from Panax ginseng...

Blood and lymphatic vascular remodeling in intervertebral disc degeneration.

A defining histological feature of the intervertebral disc (IVD) in healthy adults is its avascular and alymphatic status, which is closely related to its mode of nutrient supply and local immune home...

Adjunctive middle meningeal artery embolization with low-viscosity liquid embolic agents for acute epidural hematoma: technical considerations and a case series.

OBJECTIVE: To assess the feasibility, safety, and short-term outcomes of adjunctive middle meningeal artery (MMA) embolization using low-viscosity liquid embolic agents (1:1 diluted Onyx/DMSO and 1:9 ...