Genetic Evidence for the Benefits and Risks of Glucose-Lowering Drugs on Cardiovascular-Kidney-Metabolic Syndrome: A Drug-Target Mendelian Randomization Study.

BACKGROUND: To explore the potential benefits and risks of glucose-lowering drugs on cardiovascular-kidney-metabolic (CKM) syndrome outcomes using drug-target Mendelian randomization (MR). METHODS: Ge...

Multimodal Patient-Specific Identification of Atrial Flutter Circuits From ECG Time Series Using Explainable Machine Learning.

OBJECTIVE: Accurate pre-procedural identification of atrial flutter (AFL) mechanisms can streamline mapping and indirectly inform ablation strategy, yet surface-electrocardiogram (ECG) criteria remain...

PFKFB3 Mediated Glycolytic Reprogramming Drives Vascular Endothelial Injury Under Chronic Intermittent Hypoxia.

Metabolic-inflammatory crosstalk is a hallmark of cardiovascular pathogenesis. Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is an independent risk factor for car...

Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications.

Melatonin is a pleiotropic hormone with well-documented antioxidant, anti-inflammatory, neuroprotective, and immunomodulatory properties, making it a promising candidate for the treatment of diverse d...

The Origin and Application of Cardiomyocyte-Derived Small Extracellular Vesicles: A Systematic Review.

UNLABELLED: Background/Aims: Cardiomyocyte-derived small extracellular vesicles (CM-sEVs) have emerged as important mediators of intercellular communication in cardiovascular diseases (CVDs). However,...

Neuroimmune cross-talk in Leptospira-associated acute encephalopathy syndrome.

The Leptospira-associated acute encephalopathy syndrome (AES) is a severe neurological complication, largely affecting the endemic regions. Unlike other classical neurotropic infections, Leptospira-in...

VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair.

The dynamic interplay between vascular smooth muscle cells (VSMCs) and the immune microenvironment governs vascular repair and disease progression. This review systematically elucidates this multidime...

Endothelial ferroptosis in blood-brain barrier dysfunction and neuroinflammation: mechanisms and immune-vascular crosstalk.

Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation. In the central nervous system (CNS), most ferroptosis research has focused on neurons and glial cells...

The correlation between the atherogenic index of plasma and aortic valve calcification in the general population: a retrospective observational cohort study.

OBJECTIVE: This study aims to explore the correlation between atherogenic index of plasma (AIP) and the risk of aortic valve calcification (AVC). METHOD: This single-center retrospective cohort study ...

Correlation between circ_0092576 and Arterial Stenosis Severity and Inflammatory Status in Patients with Coronary Heart Disease and Its Clinical Value.

This study aims to investigate the predictive value of circ_0092576 for coronary heart disease (CHD) and major adverse cardiac events (MACE) risk, and to elucidate its association with the degree of c...

Trends in the hypertension care cascade under dual guideline criteria in Peru, 2014-2024: a decade of nationally representative surveys with joinpoint analysis and projections toward the WHO 2030 targets.

BACKGROUND: Prior assessments of the hypertension care cascade in Peru have covered short periods and used a single diagnostic threshold. OBJECTIVE: To describe 11-year trends (2014-2024) in the hyper...

Co-expression of MARCKS and GSDMD pathway genes in tuberculous meningitis: a multi-omics analysis of blood-brain barrier disruption.

INTRODUCTION: Tuberculous meningitis (TBM), the most severe form of Mycobacterium tuberculosis infection, is characterized by high mortality and neurological sequelae, largely attributed to blood-brai...

Neurocardiac consequences of traumatic brain injury: integrating neuroimmune, autonomic, and cerebrovascular mechanisms.

Traumatic brain injury (TBI) is increasingly recognized as a systemic disorder with consequences that extend beyond the central nervous system (CNS) to include clinically relevant cardiac dysfunction....

Immunogenetic modulation of endothelial inflammation by the LIPG -384A/C promoter variant influences COVID-19 severity.

BACKGROUND: Severe COVID-19 is characterized by dysregulated host immune responses and immune-mediated endothelial injury, culminating in microvascular dysfunction and systemic inflammation. Endotheli...

Integrative plasma proteomics and myeloid- interferon profiling reveal an AI-validated vascular- endothelial stress signature distinguishing SLE flare from remission in an Indian cohort a discovery - phase study.

BACKGROUND: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by unpredictable flares and variable clinical quiescence. Despite validated clinical indices like th...

Ultrasound-Based SECURED Protocol for Central Venous Catheterization: A Feasibility Study.

BACKGROUND: Central venous catheterization (CVC) is essential for managing critically ill patients but is associated with potential mechanical complications. Although ultrasound-guided (USG) CVC is wi...

[The variable adaptive response of human basal ganglia neurons to ischemic injury].

UNLABELLED: Arterial hypertension is a socially significant disease, one of whose complications is cerebral ischemia. Various mechanisms are involved in the adaptation of neurons to hypoxia, including...

Heterogeneity of eHealth literacy and treatment burden in older adults with heart failure: a multidimensional latent profile analysis.

BACKGROUND: Heart failure (HF) management imposes a substantial multidimensional treatment burden (BoT) on older adults. While digital health interventions offer potential solutions, their success hea...

SPISE Index (Single-Point Insulin Sensitivity Estimator): A Long-Term Predictor of Recurrence in Elderly Patients with Atrial Fibrillation After Radiofrequency Ablation.

BACKGROUND: Insulin resistance (IR) plays a significant role in the onset and progression of atrial fibrillation (AF). The single-point insulin sensitivity estimator (SPISE) index is a novel marker fo...

CHA(2)DS(2)-VASc and CHA(2)DS(2)-VA Scores as Predictors of Short- and Long-Term Mortality Following Transvenous Lead Extraction.

BACKGROUND: Multimorbidity significantly affects prognosis in patients after transvenous lead extraction (TLE). The CHA2DS2-VASc and CHA2DS2-VA scores, widely used for stroke risk stratification in at...