The predictive value of the TAPSE/PASP ratio for major adverse cardiovascular events in patients with chronic heart failure: evidence from a prolonged follow-up cohort.

BACKGROUND: The tricuspid annular plane systolic excursion to pulmonary artery systolic pressure (TAPSE/PASP) ratio is a noninvasive surrogate of right ventricular-pulmonary arterial coupling. Previou...

Pericardiectomy for constrictive pericarditis: short- and long-term outcomes in Sweden.

OBJECTIVES: Constrictive pericarditis can cause heart failure from restricted diastolic relaxation due to pericardial fibrosis. Pericardiectomy is the only curative treatment. However, evidence regard...

Astrocyte exosomes shield retina from ischemia via CaMKII-autophagy.

BACKGROUND: Retinal ischemia-reperfusion (RIR) injury impairs vision through microvascular damage and inflammation. While astrocyte-derived exosomes (ADEs) offer neuroprotection, their role in protect...

Determinants, risk score, and prognostic implications of left ventricular thrombus in ischemic cardiomyopathy assessed by cardiac magnetic resonance: a retrospective cohort study.

BACKGROUND: Left ventricular thrombus (LVT) is a significant complication in ischemic cardiomyopathy (ICM). However, factors associated with LVT have mainly been reported in patients with recent myoca...

Combined podocyte, fibrotic and echocardiographic correlates of an operationally defined subclinical cardiorenal phenotype in chronic kidney disease: an exploratory study.

Although cardiovascular complications are the most common cause of morbidity and mortality in chronic kidney disease (CKD), the detection of subclinical cardiorenal remodeling is still limited. This i...

A hybrid biofabrication platform for patient-specific aortic phantoms: from surgical rehearsal to device testing.

Fabricating high-fidelity, patient-specific aortic phantoms that possess both complex pathological features and physiological compliance remains a significant challenge for single-method manufacturing...

Evaluating and predicting of the cardiac function class and re-hospitalization in CHD with HF using IVC diameter and collapsibility index.

AIMS: Transthoracic echocardiography is widely used to assess the volume status of patients with coronary heart disease combined with heart failure (CHD-HF) because of its noninvasive and convenient n...

Prevalence and determinants of alcohol use disorder and its association with adherence to antihypertensive therapy among adult hypertensive patients in a hospital setting, Northwest Ethiopia.

METHODS: A hospital-based cross-sectional study was conducted among hypertensive outpatients at the University of Gondar Comprehensive and Specialized Hospital from January 30 to May 30, 2024. Partici...

Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders.

Oxidative stress mediated by NADPH oxidase 2 (NOX2), a major source of reactive oxygen species in the myocardium, is an important mechanism that underlies cardiac arrhythmias. NOX2 is activated by the...

Encephalomyocarditis virus impairs the blood-brain barrier by degrading tight junction proteins via AKT3-dependent autophagic and apoptotic pathways.

Encephalomyocarditis virus (EMCV) infection causes viral encephalitis; however, the mechanisms underlying blood-brain barrier (BBB) disruption remain poorly understood. Here, we demonstrate that EMCV ...

Postoperative outcomes of on- vs off-pump CABG in patients with HFrEF: a nationwide cohort study in Taiwan.

OBJECTIVE: The optimal surgical strategy for coronary artery bypass grafting (CABG) in patients with heart failure with reduced ejection fraction (HFrEF) is uncertain. This study aimed to compare post...

Pentoxifylline and cardiorenal outcomes in advanced CKD with untreated dyslipidemia: a longitudinal cohort study.

BACKGROUND: Patients with advanced chronic kidney disease (CKD) and dyslipidemia are at high risk of kidney failure and cardiovascular events, yet many do not receive lipid-lowering therapy. Pentoxify...

Retinal vascular parameters as AI-driven biomarkers for pulse wave velocity assessment: a telemedicine strategy for cardiovascular risk assessment.

BACKGROUND: Pulse wave velocity (PWV), known as the gold standard for evaluating arterial stiffness, is limited by device dependence. This study aims to explore the feasibility of retinal parameters t...

Clinical events and healthcare costs of dapagliflozin in adults with cardiovascular-kidney-metabolic syndrome in Spain: a cost-offset analysis.

AIMS: Adults with cardiovascular-kidney-metabolic (CKM) syndrome, characterized by interactions among metabolic, chronic kidney disease (CKD) and cardiovascular disease, face a high symptomatic burden...

Cardiometabolic benefits of parathyroidectomy in dialysis patients with secondary hyperparathyroidism: preliminary insights from CT radiomics and body composition analysis.

Secondary hyperparathyroidism (SHPT) contributes to mineral-bone disorders, chronic inflammation, and adverse cardiometabolic outcomes in patients undergoing dialysis. Radiomics of epicardial adipose ...

Impact of ASO conjugation and receptor binding affinity on intracellular transport of mono- and bispecific TfR- and CD98-Brainshuttle(TM) variants.

Antisense oligonucleotides (ASOs) represent a promising therapeutic modality for central nervous system (CNS) disorders, offering highly specific modulation of gene expression. However, their clinical...

Completeness and interrater reliability of the Norwegian National Electrophysiology and Ablation Registry (AblaNor).

Objectives. Data quality is a prerequisite for the use of registries. National Registry for Ablation and Electrophysiology in Norway (AblaNor) is a nationwide medical quality register of Norwegian pat...

Remimazolam for sedation in flexible bronchoscopy: A systematic review and meta-analysis of randomised controlled trials.

BACKGROUND: Remimazolam is a novel benzodiazepine increasingly used for procedural sedation and general anaesthesia. Its role in clinical use in flexible bronchoscopy remains under investigation. AIM:...

Unveiling the cognitive fog in lung cancer patients: non-invasive exploration of blood-brain barrier disruption and brain structural changes.

BACKGROUND: This study investigates the correlation between blood-brain barrier (BBB) damage and cognitive impairment in patients suffering from untreated lung cancer. The study aims to understand the...

Elevated atherogenic index of plasma is associated with severe acute kidney injury in critically ill patients with cardiovascular disease - a MIMIC-IV analysis with external validation in the eICU-CRD database.

The atherogenic index of plasma (AIP) is a lipid-based marker of cardiovascular risk, yet its prognostic value for severe acute kidney injury (AKI) in critically ill patients with cardiovascular disea...