Arrhythmias and Coronary Slow Flow: A Potential Pathogenic Link.
Coronary slow flow (CSF) is characterized by recurrent resting angina and delayed distal vessel filling, despite the absence of obstructive coronary artery disease on angiography. With the continuous ...
Curcumin Combined with Flaxseed Oil Modulates Lipid Metabolism in Hamsters Fed a High-Fat, High-Cholesterol Diet: Insights from Lipidomics.
Background/Objectives: Dyslipidemia and hepatic lipid buildup are key features of cardiometabolic disorders caused by high-fat, high-cholesterol diets. Both curcumin and flaxseed oil have been shown t...
Endothelial-to-Mesenchymal Transition Mechanisms in Vascular Remodeling of Pulmonary Hypertension.
Pulmonary arterial hypertension (PAH) is a chronic and progressive cardiopulmonary vascular disorder associated with poor clinical prognosis. Its hallmark pathological feature is sustained elevation o...
State-of-the-art management of ischemic cardiomyopathy: integrating diagnostic pathways, revascularization strategies, and guideline-directed therapy.
Ischemic cardiomyopathy (ICM) is a major cause of cardiovascular morbidity and mortality, characterized by a complex pathophysiological substrate and heterogeneous clinical trajectories. Despite decad...
EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: A translational epigenetic approach.
Atherosclerosis drives cardiovascular morbidity in diabetes, with endothelial-to-mesenchymal transition (EndMT) as a key contributor. Whereas epigenetic regulators are increasingly implicated in ather...
Associations of thyroid hormones with metabolic syndrome and coronary artery stenosis in euthyroid individuals: A cross-sectional study.
This study aimed to investigate the associations between thyroid hormones, metabolic syndrome (MetS), and coronary artery stenosis (CAS) in euthyroid patients, given the insufficient evidence on concu...
Immune cell-mediated effects of plasma lipids on heart failure: A two-step, two-sample Mendelian randomization study.
A growing number of studies have shown that plasma lipids and immune cells are related to the occurrence and development of heart failure (HF), but the causal relationship between them is unclear. The...
The clinical efficacy of Astragalus-containing Chinese patent medicines in the effective treatment of heart failure: A systematic review and network meta-analysis.
BACKGROUND: The incidence of cardiovascular diseases, particularly heart failure, has been rising year by year. Traditional Chinese medicines containing Astragalus have been widely used in clinical re...
Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.
Heart failure (HF) is a heterogeneous clinical syndrome characterized by phenotype-specific metabolic remodeling (e.g., ischemic vs. nonischemic, HF with HFrEF vs. HFpEF), with impaired metabolic flex...
Real-world off-label apixaban dosing and clinical outcomes in patients with heart failure and end-stage kidney disease.
Apixaban plays a crucial role in preventing cardioembolic events in patients with nonvalvular atrial fibrillation (NVAF). However, in clinical practice, physicians often adjust apixaban dosing based o...
Development and validation of a prediction model for ischemic stroke recurrence risk in patients with ischemic stroke and atrial fibrillation.
BACKGROUND: The recurrence rate of atrial fibrillation (AF)-related ischemic stroke (IS) remains persistently high, significantly increasing patient mortality, disability, and socioeconomic burden. Th...
[Dual role and therapeutic potential of TREM2 in atherosclerosis].
Triggering receptor expressed on myeloid cells 2 (TREM2) is a key transmembrane immune receptor that is specifically highly expressed in myeloid cells, particularly macrophages, within atherosclerosis...
In-depth analysis of retinal RNA transcriptome sequencing in a rat model of hypertensive retinopathy.
OBJECTIVES: Hypertensive retinopathy is a microvascular complication caused by systemic hypertension and can lead to severe visual impairment. At present, the molecular mechanisms of this disease rema...
[Development and reliability and validity testing of the Medication Literacy Scale for patients with chronic heart failure].
OBJECTIVES: Chronic heart failure (CHF) is characterized by high prevalence, high mortality, and high readmission rates. Optimized combination pharmacotherapy is the main approach to controlling clini...
The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease that occurs due to fibrotic remodeling of the pulmonary vessels. This leads to increased pressure overload onto the right...
The Pivotal Role of Plant Derivatives and Eicosanoid Signaling Modulation in Counteracting Cardiomiopathy.
Eicosanoids and their receptors act as key regulators of inflammation, calcium homeostasis, mitochondrial function, and cardiomyocyte survival, thereby contributing to the onset and progression of car...
Temporal RT-qPCR-Based Porcine Cardiac Molecular Profiling for Post-Mortem Interval Estimation: Predictive Modeling.
Estimating the post-mortem interval (PMI) remains a major challenge in forensic pathology, particularly beyond the earliest postmortem phases. RNA-based markers measured by RT-qPCR have been proposed ...
Bioinformatics Identification and Molecular Docking Validation of Post-Translational Modification-Related Hub Genes as Diagnostic Biomarkers and Therapeutic Targets in Myocardial Fibrosis.
Myocardial fibrosis is a common pathological feature of multiple cardiovascular diseases, including heart failure, hypertension, and myocardial infarction, and is associated with poor prognosis. Despi...
A 35-Year-Old Woman With Recurrent Hypertriglyceridemia-Induced Pancreatitis in Pregnancy Managed With Fenofibrate and Plasmapheresis.
BACKGROUND Hypertriglyceridemia-induced pancreatitis in pregnancy is a rare condition that requires emergency management to prevent maternal morbidity and fetal loss. Physiological lipid shifts during...
Clonal reshaping and clinical outcomes after rechallenge in ICI-associated myocarditis: integrated single-cell and TCR repertoire analysis.
BACKGROUND: Immune checkpoint inhibitor-associated myocarditis (ICIAM) poses significant challenges for cancer immunotherapy, particularly regarding the safety and efficacy of immune checkpoint blocka...