The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension.
A, M., S, H., G, M., AH, B., RD, S., M, T., I, M., Y, I.M., T, K., & K, H. (2026). The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension.. Medical sciences (Basel, Switzerland). https://doi.org/10.3390/medsci14020273
A M, S H, G M, AH B, RD S, M T, et al. The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension.. Medical sciences (Basel, Switzerland). 2026; doi: 10.3390/medsci14020273
A M, S H, G M, et al. The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension.[J]. Medical sciences (Basel, Switzerland). 2026. DOI: 10.3390/medsci14020273.
@article{a2026,
author = {Mohammed A and Hussein S and Mahdi G and Behnoush AH and Schultz RD and Tagliafierro M and Mason I and Ishisaka Mori Y and Kuno T and Hosseini K},
title = {The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension.},
journal = {Medical sciences (Basel, Switzerland)},
year = {2026},
doi = {10.3390/medsci14020273},
note = {PMID: 42346812},
}
TY - JOUR AU - Mohammed A AU - Hussein S AU - Mahdi G AU - Behnoush AH AU - Schultz RD AU - Tagliafierro M AU - Mason I AU - Ishisaka Mori Y AU - Kuno T AU - Hosseini K TI - The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension. T2 - Medical sciences (Basel, Switzerland) PY - 2026 DO - 10.3390/medsci14020273 AN - PMID:42346812 ER -
Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease that occurs due to fibrotic remodeling of the pulmonary vessels. This leads to increased pressure overload onto the right ventricle, resulting in complications such as heart failure. Pulmonary endarterectomy (PEA) remains the gold standard of treatment for CTEPH, yet many patients experience life-threatening perioperative complications, including refractory right ventricular failure, reperfusion pulmonary edema, and endobronchial hemorrhage. Extracorporeal membrane oxygenation (ECMO) has been used as a form of mechanical circulatory support to aid recovery in patients with perioperative complications in the context of CTEPH. This review identifies preoperative risk factors, including pulmonary vascular resistance, high body mass index, and elevated neutrophil-to-lymphocyte ratios. It also identifies differences in ECMO configuration, with veno-arterial ECMO preferred for hemodynamic instability and veno-venous ECMO for respiratory failure. Finally, we posit that, based on contemporary literature, the implementation of early ECMO in decompensated patients may be associated with reduced hospital mortality, and in those who survive beget excellent mid-term survival.