Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets.

Obesity and cardiovascular disease are major, globally prevalent, and closely interrelated health challenges. Cardiac fibrosis represents the common pathological endpoint of multiple cardiac diseases....

The gut-liver-kidney-brain axis in Wilson disease: copper speciation-flux and barrier-mediated organ crosstalk.

Wilson disease (WD) has long been framed as a hepatocentric disorder of copper accumulation. That view is now giving way to a broader model centered on the gut-liver-kidney-brain axis. In WD, copper i...

The role of the bidirectional regulatory network between immune cells and stromal cells in cardiac repair and fibrosis following myocardial infarction.

Heart failure following myocardial infarction (MI) is a major complication affecting long-term prognosis of patient, with its core pathological processes being ventricular pathological remodeling and ...

The effectiveness of motivational interviewing on self-management in older adults with hypertension and frailty: study protocol for a randomized controlled trial.

BACKGROUND: Frailty and hypertension frequently coexist in older adults, posing substantial challenges to self-management and increasing the risk of adverse outcomes. Standard health education has sho...

Association between impaired peripheral thyroid hormone sensitivity and coronary heart disease in type 2 diabetes: the potential mediating role of albumin.

BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with a high risk of cardiovascular mortality, primarily from coronary heart disease (CHD). Thyroid hormone (TH) sensitivity and albumin indepe...

Integrating lipid-related composite indices and explainable machine learning for coronary heart disease risk assessment.

BACKGROUND: Composite indices integrating inflammation and lipid metabolism have emerged as promising markers for coronary heart disease (CHD), yet their comparative performance and discriminative abi...

A high-fat/high-sucrose/high-cholesterol diet leads to early indications of metabolic dysfunction-associated steatohepatitis-like lesions in obese diabetic mice.

Chronic hyperlipidemia and/ or hyperglycemia can impair various organs, such as the liver, kidney, and pancreas, through metabolic abnormalities. Metabolic dysfunction-associated steatohepatitis (MASH...

Japanese-Style Diet and LOX-Index in Japanese Municipal Workers.

Japanese-style diet has been reported to be associated with decreased risk of cardiovascular disease. However, no study has examined the association between a Japanese-style diet and LOX-index, which ...

[Survey of Pharmaceutical Interventions in Outpatient Cancer Chemotherapy].

In recent years, cancer chemotherapy has been administered in an outpatient setting; therefore, patient self-management of adverse events is an important issue. Pharmaceutical interventions were perfo...

Development of Nucleic Acid-Loaded Nanobubbles for Ultrasound-Mediated Therapeutic Applications.

Ultrasound has attracted considerable attention not only as a diagnostic imaging modality but also as a physical trigger for drug delivery system (DDS). Ultrasound irradiation applied in combination w...

[The role of lipid metabolism disorders in the activation of cellular aging markers in atherosclerosis in elderly and senile individuals.].

Atherosclerosis is considered as one of the leading age-associated diseases, the development of which is closely related to disorders of lipid metabolism, chronic inflammation and activation of cellul...

Pre-pregnancy evaluation of essential hypertensive women with poor obstetric history.

OBJECTIVE: Essential hypertension is linked to increased maternal and perinatal risks. The aim of this study was to assess women with essential hypertension and poor obstetric history before conceptio...

Impact of physical activity associated with bariatric surgery on systemic arterial hypertension control: a systematic review.

BACKGROUND: Obesity is a highly prevalent condition frequently associated with systemic arterial hypertension (SAH). Bariatric surgery (BS) is an effective strategy for weight loss and has been shown ...

Association Between Apelin Gene -1860T>C (rs56204867) Polymorphism and Coronary Artery Disease in a Syrian Cohort.

PURPOSE: Apelin is a secreted peptide hormone involved in vasodilation, fluid homeostasis, and angiogenesis, and is therefore considered an important regulator of cardiovascular physiology. The APLN T...

Admission NT-proBNP provides stronger prognostic discrimination than the AHEAD score for 1-year mortality in hospitalized acute heart failure: A retrospective cohort study.

BACKGROUND: Both admission N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the AHEAD score predict prognosis in acute heart failure, but their comparative and complementary value for admissi...

[Errors in the diagnosis of chronic heart failure among outpatient elderly patients with type 2 diabetes mellitus.].

Objective - to study the incidence of chronic heart failure (CHF), including clinical manifestations, assessment of the concentration of the precursor of the brain natriuretic peptide (Nt-proBNP) in e...

Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.

BACKGROUND: Simulated microgravity, modeled by head-down tilt (HDT), induces cephalad fluid shifts that perturb intracranial hemodynamics and may affect cognitive function. However, the temporal adapt...

Brain Endothelial Glycocalyx as a Blood-Facing Translational Interface in Alzheimer's Disease: Beyond "Leaky" Barriers Toward Repair-First Stratification.

Alzheimer's disease (AD) pathogenesis is increasingly recognized as involving blood-brain barrier (BBB) and neurovascular unit (NVU) destabilization. The brain endothelial glycocalyx-a blood-facing gl...

Prevalence and Predictors of Dyslipidemia and Diabetes Mellitus Among cART-Treated HIV Patients in Western Ethiopia: A Cross-Sectional Study.

BackgroundCombination of antiretroviral therapy (cART) has improved the life expectancy of HIV patients. Yet, it can also increase the risk of metabolic dysfunction, including dyslipidemia and diabete...

Triglyceride-glucose related index and its association with coronary heart disease risk in patients with metabolic dysfunction-associated steatotic liver disease: a retrospective analysis based on type 2 diabetes mellitus.

BACKGROUND: The triglyceride-glucose (TyG) related index, as an emerging indicator of insulin resistance, has been shown to be closely associated with the clinical status (incidence of cardiovascular ...