An integrated multi-omics study of key mediators and therapeutic targets for doxorubicin-induced atrial fibrillation.
BACKGROUND: Doxorubicin (DOX), a widely used chemotherapeutic agent for cancer patients, is associated with a significant risk of inducing atrial fibrillation (AF), a serious cardiac complication that...
Basement Membrane-Related Genes C1QTNF3, PTGER2, CAMK2N1, PRSS36, and B3GNT7: Novel Biomarkers for Coronary Artery Disease.
BACKGROUND: Basement membrane-related genes (BMRGs) play a pivotal role in the pathogenesis of several diseases. However, their association with coronary artery disease (CAD) remains unexplored. There...
Long-Chain Fatty Acid Oxidation Disorder Genes: A Comprehensive Genetic Database of LC-FAOD Variants, Genotypes, and Phenotypes.
Long-chain fatty acid oxidation disorders (LC-FAODs) are characterized by the inability to metabolize long-chain fatty acids. Serious clinical manifestations occur, including cardiomyopathy, hypoglyce...
Ferroptosis in arterial atherosclerosis: mechanistic hypotheses, cell type specific vulnerabilities, translational biomarkers, and therapeutic opportunities.
Despite significant progress in lipid-lowering and anti-thrombotic therapies, atherosclerosis remains a leading cause of myocardial infarctions and ischemic strokes. Residual risk persists, often link...
Five-Year Outcomes of Paclitaxel-Coated Balloons in Patients with Diabetes from the BIOLUX P-III Single-Arm Study.
PURPOSE: Long-term outcomes of paclitaxel-coated drug-coated balloons (DCBs) in patients with diabetes mellitus (DM) and infrainguinal peripheral arterial disease (PAD) are incompletely defined. In th...
Long-Term Health Outcomes in Individuals With Confirmed Versus Unconfirmed Undiagnosed Diabetes Based on Oral Glucose Tolerance Test: Findings From the Tehran Lipid and Glucose Study.
BACKGROUND: To evaluate the prognostic performance of the single-sample confirmatory definition of undiagnosed diabetes on outcomes, including hypertension, chronic kidney disease (CKD), cardiovascula...
Association between air pollution and incident cardiovascular diseases among a population with cardiovascular-kidney-metabolic syndrome stages 0-3: the first evidence from the China Health and Retirement Longitudinal Study.
BACKGROUND: The longitudinal associations between air pollution exposure and incident cardiovascular diseases (CVDs) among individuals with cardiovascular-kidney-metabolic (CKM) syndrome remains limit...
Salvianolic Acid B Alleviates Atrial Fibrillation-Associated Fibrosis With Modulation of COL1A2 and the PI3K-AKT Pathway.
BACKGROUND: Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is strongly associated with atrial fibrosis. Salvianolic acid B (Sal-B), a bioactive compound extracted from Salvia miltior...
Meteorin-like controls metabolic adaptations and physiological myocardial remodeling in pregnancy and lactation.
INTRODUCTION: The gestation-lactation period involves profound but reversible cardiac remodeling. Meteorin-like (Metrnl) has emerged as a regulator of cardiac metabolism in pathological settings, but ...
Case report: Pediatric vascular Behçet's disease with prominent arterial involvement: a case series of five patients.
BACKGROUND: Vascular Behçet's disease (VBD) rare and severe subtype of Behçet disease characterized by vascular inflammation. Its prevalence in the pediatric population is extremely low. This case ser...
MicroRNA-383-5p regulation of NADPH oxidase 4 alleviates hemorrhagic transformation and improves acute outcomes after endovascular recanalization in acute ischemic stroke.
BACKGROUND: Hemorrhagic transformation (HT) following reperfusion therapy is associated with poor outcomes in patients with acute ischemic stroke. Here, we determined the role of microRNA-383-5p (miR-...
Transport Across the Blood-Brain Barrier.
The blood-brain barrier (BBB) is a dynamic barrier essential for maintaining the microenvironment of the brain. Although the special anatomical features of the BBB determine its protective role for th...
Modeling of Tumor Cell Adhesion, Extravasation, and Sorting in a Microvascular System.
Blood flow dynamics in microvessels dictate the transport modes of circulating tumor cells (CTCs) and, consequently, influence their metastatic potential. While extensive biochemical and biological st...
Tumor Metastasis in the Microcirculation.
Tumor cell metastasis through blood circulation is a complex process and is one of the great challenges in cancer research as metastatic spread is responsible for ∼90% of cancer-related mortality. Tum...
The Examination of Arterial Function and Mechanotransduction Through Brachial Arteries via Flow-Mediated Dilation.
Cardiovascular disease remains one of the leading causes of mortality worldwide, with endothelial dysfunction playing a pivotal role in its initiation and progression. Early detection and accurate eva...
Abdominal Aortic Aneurysm Pathomechanics, Current Understanding and Emerging Directions: A Perspective for 2025 and Beyond.
Abdominal aortic aneurysms (AAAs) are permanent, local expansions of the abdominal segment of the aorta that can potentially be fatal if progressing to rupture. AAAs are rarely found in patients under...
A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation.
This chapter delves into the biomechanics and mechanobiology of the right side of the human circulatory system, focusing on the vascular pulmonary circulation driven by the right ventricle. Pulmonary ...
Endothelial Nuclear and Cytoskeletal Responses to Mechanical Stresses.
The ability of vascular endothelium to sense and respond to the mechanical stimuli generated by blood flow is pivotal in maintaining arterial homeostasis. A steady laminar flow tends to provide athero...
Vascular Mechanobiology: From Membrane to Nucleus.
The vascular wall is continuously exposed to complex hemodynamic forces in vivo due to blood flow. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) experience distinct mechanical stres...
Glycosaminoglycans and Their Role in Capillary Walls.
Glycosaminoglycans (GAGs) are polysaccharide chains that extend into the vascular lumen and are embedded throughout the capillary wall. They have a multitude of biophysical and biochemical roles inclu...