A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation.

This chapter delves into the biomechanics and mechanobiology of the right side of the human circulatory system, focusing on the vascular pulmonary circulation driven by the right ventricle. Pulmonary ...

Endothelial Nuclear and Cytoskeletal Responses to Mechanical Stresses.

The ability of vascular endothelium to sense and respond to the mechanical stimuli generated by blood flow is pivotal in maintaining arterial homeostasis. A steady laminar flow tends to provide athero...

Vascular Mechanobiology: From Membrane to Nucleus.

The vascular wall is continuously exposed to complex hemodynamic forces in vivo due to blood flow. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) experience distinct mechanical stres...

Glycosaminoglycans and Their Role in Capillary Walls.

Glycosaminoglycans (GAGs) are polysaccharide chains that extend into the vascular lumen and are embedded throughout the capillary wall. They have a multitude of biophysical and biochemical roles inclu...

The Molecular Structure of the Endothelial Glycocalyx. Models to Interpret High-Resolution Imaging of an Ordered Structure for the Molecular Filter at the Microvascular Wall.

The endothelial glycocalyx is a complex fibrous network of molecules that extends from the endothelial cell membrane for distances that range from less than 0.3 micron to several microns. The mechanis...

Endothelial Surface Glycocalyx in Vascular Functions and Diseases.

Endothelial cells (ECs), which form the inner lining of the vasculature, are perpetually exposed to mechanical stimuli from blood flow. Their capacity to sense and respond to these forces is essential...

Atypical eclampsia without severe hypertension - the role of ophthalmic artery Doppler and sFlt-1/PlGF ratio: a case report.

Eclampsia remains one of the most severe obstetric emergencies associated with substantial maternal and perinatal morbidity and mortality. Although classically regarded as a hypertensive complication ...

Comparative Effectiveness and Safety of Interventions for Atrial Fibrillation in Heart Failure: A Network Meta-Analysis of Randomized Trials.

BACKGROUND: Patients with HF and AF face high risks of death and HF decompensation, yet the comparative effectiveness of commonly used AF management strategies remains uncertain. This study is aimed a...

An Optimized Heart Failure Triaging Protocol to Reduce Avoidable Hospitalizations and Total Costs of Care.

Heart failure remains a leading cause of potentially avoidable hospital admissions throughout the United States and a significant driver of unnecessary, avoidable costs within value-based care program...

Propofol and Salvianolic Acid a Synergistically Attenuate LPS-Induced Myocardial Pyroptosis in Diabetic Mice via the SIRT1/HMGB1 Pathway.

BACKGROUND: We investigated whether propofol (PPF) combined with salvianolic acid A (SAA) confers synergistic cardioprotection in diabetic sepsis. METHODS: Diabetic-septic mice and high-glucose/LPS-tr...

Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study.

OBJECTIVE: This research investigates the correlation between nine polymorphic variants and the incidence of hypertension and its clinical manifestations in the Ellikqala District in the Republic of K...

Mediation by atherogenic index of plasma of the association between body roundness index and cognitive impairment in older Chinese people: an analysis using health check-up data.

OBJECTIVE: The objective of this large sample cross-sectional study was to investigate the relationships between body roundness index (BRI), atherogenic index of plasma (AIP), and cognitive impairment...

Cardiovascular risk in inflammatory bowel disease: focus on lipids and visceral adipose tissue.

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic immune-mediated diseases that are increasingly recognized as systemic diseases with significant cardiov...

The optimal dose of brisk walking for improving blood pressure in hypertensive patients: a systematic review and bayesian meta-analysis of randomized controlled trials.

BACKGROUND: Hypertension is one of the most common chronic diseases worldwide. Brisk walking is regarded as a safe and effective exercise modality for blood pressure reduction; however, its optimal ex...

The SGK1/ENaC axis in renal injury during salt-sensitive hypertension: from sodium sensing to inflammation.

Salt-sensitive hypertension (SSHT) is commonly framed as a disorder of renal sodium transport and vascular dysfunction. Yet increasing evidence indicates that immune cells also detect sodium excess an...

Best evidence summary of digital health interventions for self-management in patients with coronary artery disease.

OBJECTIVE: To systematically identify and synthesize the best available evidence on digital health interventions supporting self-management in patients with coronary artery disease (CAD). The aim of t...

Metabolomics-Driven Precision Prevention and Treatment of Heart Failure with Traditional Chinese Medicine: From Mechanistic Insights to Metabolic Network Regulation.

Heart failure (HF), as the terminal clinical stage of diverse cardiovascular diseases, involves complex pathological mechanisms. Conventional Western medicines, which typically target individual molec...

Cardiac myocyte contractility, calcium dynamics, and morphology in Zucker diabetic fatty female and male rats - lacking data in this model of obesity and diabetes: A review.

Diabetes mellitus (DM) represents an increasing global health burden with type 2 diabetes mellitus (T2DM) accounting for most cases. T2DM is associated with microvascular and macrovascular complicatio...

Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.

BACKGROUND: Severe dengue is a vascular immunopathology characterized by plasma leakage, thrombocytopenia, hemorrhage, and, in its most critical form, dengue shock syndrome. Although NS1-mediated endo...

Circadian control of immune homeostasis in cardiovascular health and disease.

The circadian system is an important regulator of cardiovascular immune homeostasis. Emerging evidence suggests that daily timing of immune responses may influence cardiovascular disease progression b...