Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs.

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting ...

Persistent hypoxia with mosaic attenuation despite negative CT pulmonary angiography in chronic thromboembolic pulmonary hypertension.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but serious complication of acute pulmonary embolism. It may be clinically silent and often presents with non-specific symptoms, making ...

Subclinical ocular microvascular involvement in primary antiphospholipid syndrome and antiphospholipid antibody carriers.

OBJECTIVES: Investigate the role of antiphospholipid antibodies (aPL) in determining subclinical microvascular alterations in patients with primary antiphospholipid syndrome (PAPS) and antiphospholipi...

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy.

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state a...

Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat model.

Pharmacological inhibition of the chloride-bicarbonate exchanger pendrin with PDSinh-C01 potentiates the diuretic action of furosemide in healthy mice. Because pendrin contributes to acid-base regulat...

Metallomic Dysregulation and Cardiovascular Disease: Essential Trace Elements, Non-essential Metal Exposure, and Heart Failure Risk: A Systematic Review.

Heart failure (HF) affects over 64 million people worldwide, with five-year mortality rates rivaling solid-organ malignancies. Despite advances in neurohormonal therapy, many patients continue to prog...

The gut microbiome and allograft outcomes: implications for heart transplantation.

Heart transplantation remains the gold standard therapy for patients with end-stage heart failure. However, post-transplant complications are considerable. Emerging evidence implicates the gut microbi...

Transferrin-Conjugated Polymeric Nanoparticles via Polymerization-Induced Self-Assembly for Enhanced BBB Transport and Glioblastoma Therapy.

Transferrin-coated nanoparticles show promise in delivering chemotherapeutic drugs across biological barriers for treating glioblastoma multiforme (GBM). Employing a synthetic approach integrating adv...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study.

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patien...

Stroke prevention using oral anticoagulants among patients with atrial fibrillation: a qualitative study of Australian general practitioners.

BACKGROUND: To examine Australian general practitioners' (GPs) perspectives on initiating oral anticoagulation for stroke prevention in patients with atrial fibrillation, and their approaches to monit...

Real-life data is very useful for gaining a better understanding of care in practice and identifying areas for improvement. This study aimed to assess changes in the clinical characteristics, care and...

A Deep Learning Framework Based on Denoising and 2D Image Encoding for Arrhythmia Classification.

Electrocardiogram (ECG) signals are essential for arrhythmia detection; however, they are frequently degraded by noise during acquisition, and their evaluation is vulnerable to data-leakage and patien...

Indoxyl Sulfate Promotes Vascular Calcification in Association with Oxidative Stress and Activation of ERK and Wnt/β-Catenin Signaling Pathways.

Vascular calcification (VC) is a major complication of chronic kidney disease (CKD) that is strongly associated with cardiovascular mortality. While indoxyl sulfate (IS), a protein-bound uremic toxin,...

See the (In)Visible: Infrared Thermography for Characterizing Thermal Patterns Associated with Peripheral Arterial Disease and Diabetes Mellitus.

Background/Objectives: Peripheral arterial disease (PAD) and diabetes mellitus (DM) may produce different and overlapping plantar thermal patterns. This study descriptively characterized whole-foot te...

LCN2 Associated With the Bidirectional Cardio-Kidney Link in Patients With Type 2 Diabetes and Cardiovascular-Kidney-Metabolic Syndrome.

BACKGROUND Despite the well-established epidemiological association between diabetic kidney disease (DKD) and coronary artery disease (CAD) in patients with T2DM, which reflects a core feature of card...

Severe Tricuspid Regurgitation: Traumatic Papillary Muscle Rupture Mimicking Infective Endocarditis-A Case Report.

BACKGROUND Differentiating traumatic tricuspid regurgitation (TR) from infective endocarditis (IE) is clinically crucial in patients presenting with abnormal tricuspid valve findings after blunt chest...

Genetic Variants in HSP70 Family and BAG Co-Chaperone Genes: Associations with Coronary Artery Disease Risk and Potential Regulatory Effects.

Heat shock proteins of the HSP70 family and their BAG co-chaperones regulate responses to oxidative stress, inflammation, apoptosis, and ischemia, all central to coronary artery disease (CAD) pathogen...

Integrated Bulk and Single-Cell Transcriptomic Analyses Identify a FOLR2(+) Tissue-Resident Macrophage-Associated Lysophagy Gene Module in Heart Failure.

Objectives: Heart failure (HF) arises from multiple interrelated pathological processes. Among these, lysosomal impairment and loss of autophagic homeostasis are increasingly recognized as important c...

Targeting the Notch Signaling Pathway to Treat Atherosclerosis.

Atherosclerosis remains the principal underlying cause of myocardial infarction, ischemic stroke and peripheral artery disease, and its progression reflects a complex interplay between lipid accumulat...

[Research progress and applications of biologically derived materials in scleral reconstruction].

OBJECTIVE: To review the research progress and clinical applications of biologically derived materials in scleral reconstruction. METHODS: A comprehensive review of recent domestic and international l...