Angiographic Demonstration of a Transverse Sinus Fenestration Coexisting with a Kobayashi Type 4B Torcular Variant: Case Report.

This report describes an exceptionally rare case of an incidental angiographic fenestration of a dominant right transverse sinus (TS) associated with a Kobayashi type 4B torcular variant in a 54-year-...

Engineering ApoE3-Targeted NIR-Responsive Liposomes for Multimodal Inhibition of Amyloid-β Aggregation and Acetylcholinesterase Activity.

Alzheimer's disease (AD) is characterized by progressive neurodegeneration and cognitive decline, largely driven by amyloid-β (Aβ) aggregation and dysregulated acetylcholinesterase (AChE) activity. Wh...

From chemical oscillators to biological synchrony: a programmable reaction-diffusion model for studying signal coordination in cardiomyocyte networks.

The self-organization of asynchronous rhythms into synchronized beating in in vitro cardiomyocyte networks is a fundamental problem in systems biology research. Inspired by the dynamics of chemical os...

MCL1 Promotes Endothelial Senescence and Atherosclerosis via Glycolytic Reprogramming-Induced H4K12 Lactylation.

Accumulation of senescent endothelial cells (ECs) accelerates atherosclerosis, yet the molecular orchestrators linking metabolic dysregulation to epigenetic reprogramming during EC senescence remain e...

Gaseous Air Pollutant Exposure and Atherosclerosis: A Systematic Study Integrating Multi-Omics and Network Toxicology.

Gaseous air pollution is a major environmental risk factor for atherosclerosis, yet the specific molecular networks linking Gaseous air pollution to atherosclerosis are not fully characterized. This s...

Pulsed Field Versus Cryoballoon Ablation for Atrial Fibrillation: Procedural Outcomes and Hemolysis-Related Laboratory Changes in a Single-Center Pilot Study.

Background and Objectives: Pulsed field ablation (PFA) and cryoballoon ablation (CRYO) are established approaches for pulmonary vein isolation in atrial fibrillation (AF). Given emerging concerns rega...

Empagliflozin Improves Post-Infarct Heart Failure Through Fibroblast Growth Factor-21 and Ketone Body Oxidation Pathway.

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors improve outcomes in heart failure, but the mechanisms remain incompletely understood. Metabolic remodeling has been proposed as a key medi...

[Arterial hypertension and bronchial asthma: phenotype, cardiovascular complications, and independent predictors - an analysis of 57,396 patients from a hypertension registry].

BACKGROUND: The combination of arterial hypertension (AH) and bronchial asthma (BA) presents a complex clinical challenge that notably elevates cardiovascular risk. Real-world data are scarce regardin...

[Screening for Helicobacter pylori infection in patients with acute myocardial infarction and stable coronary artery disease: prevalence and risk factors (a single-center study)].

AIM: To evaluate the prevalence and identify risk factors for Helicobacter pylori infection in patients with acute myocardial infarction (AMI) and stable coronary artery disease (CAD). MATERIALS AND M...

En kvinne i 60-årene med rødt øye, tåkesyn og allmennsymptomer.

BACKGROUND: Panuveitis is a severe intraocular inflammatory condition that can have infectious, autoimmune, or neoplastic aetiologies. In rare cases, it may represent an early manifestation of systemi...

Differential associations of resting heart rate and heart rate variability indices with cardiovascular and coronary heart disease mortality risk: the prospective KORA study.

Limited data exist on the relationship of resting heart rate (RHR) and heart rate variability (HRV) indices with cardiovascular (CVD) and coronary heart disease (CHD) mortality in individuals with and...

Comparative outcomes of balloon-expandable versus self-expanding transcatheter aortic valves: insights from a large-scale German registry.

BACKGROUND: While transcatheter aortic valve replacement (TAVR) has become an established alternative to surgical aortic valve replacement (SAVR), the comparative outcomes of balloon-expandable (BE) a...

Artificial intelligence-enhanced management system for secondary prevention of coronary heart disease: a randomized clinical trial.

BACKGROUND: Secondary prevention of coronary heart disease (CHD) remains suboptimal due to fragmented care and therapeutic inertia. While digital health interventions offer a promising strategy, few e...

Association of albumin-bilirubin score with clinical severity and outcome in patients with decompensated heart failure: a retrospective cohort study.

BACKGROUND: The Albumin-Bilirubin (ALBI) score is a simple marker of hepatic function that may reflect systemic congestion in heart failure. Therefore, the present retrospective cohort study aimed to ...

Precision Ligation of the Left Anterior Descending Coronary Artery Using Anatomical Landmarks in a Murine Myocardial Infarction Model.

Permanent ligation of the left anterior descending (LAD) coronary artery is the most widely used approach for establishing mouse models of myocardial infarction (MI) in preclinical cardiovascular rese...

Auricular Acupressure for Managing Nausea-Vomiting, Pain and Fatigue After Liver Arterial Chemoembolization and Hepatic Arterial Infusion Chemotherapy.

Patients undergoing transarterial chemoembolization or hepatic arterial infusion chemotherapy frequently experience nausea, vomiting, pain, fatigue, sleep disturbance, and appetite loss during hospita...

Arterial versus Venous Watershed Localization for Nonpalpable Pulmonary Nodules: A Retrospective Study.

Accurate localization of nonpalpable pulmonary nodules is critical for successful surgical resection. This study aimed to evaluate the feasibility and safety of the watershed localization method (WALM...

Ultrasound-Controlled Blood-Brain Barrier (BBB) Opening in a BBB-Glioblastoma Microfluidic Chip for Drug Delivery Studies.

The blood-brain barrier (BBB) is a major obstacle to treating glioblastoma (GBM) by restricting the entry of most therapeutic molecules into the brain. Interspecies differences in BBB structure and fu...

Direct oral anticoagulants in elderly patients with atrial fibrillation: a decade-long nationwide retrospective cohort study.

OBJECTIVE: To examine oral anticoagulant (OAC) prescription patterns and clinical outcomes, among elderly patients with atrial fibrillation (AF) during the era of widespread direct oral anticoagulant ...

Identification of Pro-Atherogenic Microenvironment-Associated Molecular Signatures in Response to Key Effective PM2.5 Constituents Using a Blood-Brain Barrier-Immune Microenvironment Platform.

Fine particulate matter (PM2.5) has been associated with adverse central nervous system (CNS) outcomes, yet it remains unclear how PM2.5 constituents penetrate the blood-brain barrier (BBB) and which ...