Engineered heart-liver axis nanoregulators synergize autophagy activation and systemic metabolic reprogramming against atherosclerosis.
Atherosclerosis (AS) is the most important pathological basis for cardiovascular diseases worldwide. However, the current mainstream therapeutic strategies for AS only target isolated pathological lin...
Evidence summary of nursing care of arterial drug administration and catheter management for HAIC in hepatocellular carcinoma.
BACKGROUND: This study aimed to summarize and grade the existing evidence on continuous hepatic artery infusion chemotherapy (HAIC) arterial drug administration and catheter care, providing evidence-b...
Mechanical vs. sutureless aortic valve replacement: clinical outcomes and the contribution of preoperative multislice CT.
INTRODUCTION: Heart valve disease is a significant cause of morbidity and mortality, and aortic valve replacement (AVR) is a common treatment option. Recently, sutureless biological valves have gained...
Hypertensive disorders of pregnancy and GLP-1 receptor agonist timing: a systematic review and meta-analysis.
PURPOSE: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), used to treat type 2 diabetes and obesity, may improve metabolic health before conception. However, their association to hypertensive di...
Dual-Metal Regulation of Cardiac Remodeling: Targeting the LOXL2-Ferroptosis Axis in Metal-Induced Cardiac Dysfunction.
Cardiac remodeling is driven by progressive extracellular matrix stiffening and cardiomyocyte loss. Cardiomyocyte death arising from the progression of fibrosis and ferroptosis, which are regulated by...
Successful destination therapy after stepwise mechanical circulatory support in a patient with cardiogenic shock following mechanical aortic valve replacement.
Patients with mechanical aortic valve replacement and end-stage heart failure present major challenges when mechanical circulatory support is required, as transvalvular devices such as the Impella 5.5...
Polysaccharide-driven gut microbial metabolism in neurodegenerative brain diseases: from SCFAs and tryptophan catabolites to neuroinflammatory regulation.
The gastrointestinal tract constitutes the principal anatomical interface of the microbiota-gut-brain axis (MGBA), orchestrating neuroimmune and metabolic crosstalk. Dysregulation within this network ...
Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects.
Extracellular vesicles (EVs) are intercellular mediators in prokaryotic and eukaryotic systems that have the potential to regulate various physiological and pathological processes in recipient cells. ...
Following your heart as it takes shape.
A novel computational pipeline reveals patterns of tissue movement and growth in early heart formation and advances virtual modeling of development.
Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala.
BACKGROUND: Hypertension is a leading global cause of morbidity and mortality, especially in low- and middle-income countries, where low healthcare access limits diagnosis and treatment. Community hea...
Neurocognitive outcomes after treatment of unruptured anterior communicating artery aneurysms - a systematic review.
Cognitive changes after treatment of ruptured anterior communicating artery (AComA) aneurysms have been recognized for decades. Whether such deficits occur after elective treatment of unruptured aneur...
Decoding Cardiac Development and Maturation at Single-Cell and Spatial Transcriptomic Resolution.
Recent advances in single-cell transcriptomics have revolutionized our understanding of cardiac development and maturation by resolving cellular heterogeneity, delineating lineage trajectories, and un...
Decoding Cardiovascular Disease Through Spatial Proteomics.
Cardiovascular function is tightly linked to tissue architectures, where the spatial organization of cells, extracellular matrix (ECM), vascular networks, and remodeling processes governs physiologica...
Dynamic stiffness enables stage-specific properties mediating functional endothelialization on vascular implants.
Achieving healthy, functional endothelialization represents the goal of neointima healing in cardiovascular implants but remains challenging due to strategies that fail to adapt dynamically to complex...
Carnosine-Related Metabolism in Rat Cardiomyocytes and Human Heart Tissue.
The therapeutic potential of carnosine in healthy and diseased heart models is promising; however, the understanding of carnosine and β-alanine metabolism in cardiac tissue is lacking. Exploring how t...
Cardiovascular outcome of glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitor on end-stage kidney disease patients with heart failure: an emulated target trial in patients with diabetes.
Patients with end-stage kidney disease (ESKD) receiving maintenance dialysis have a high burden of heart failure (HF), with cardiovascular disease the leading cause of death, yet are largely excluded ...
Low-intensity pulsed ultrasound-mediated nose-to-brain co-delivery of β-blockers and aPD-L1 enhances glioblastoma immunotherapy.
Intranasal delivery offers a direct route to the brain, circumventing the blood-brain barrier (BBB) and minimizing systemic toxicity. However, its efficiency is mainly limited by the nasal mucosal bar...
S100A8/A9 and S100A12 Proteins and Macrophage Polarization: Therapeutic Targets in Atherosclerosis.
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, immune cells, and fibrotic tissue within the arterial wall. Among the immune cells that drive this proces...
Congenital Anomalies and Variations of the Carotid and Vertebral Arteries: A Case-Based Imaging Review.
The carotid and vertebral arteries are critical components of the cerebral circulation, supplying the brain and spinal cord. Their embryologic development involves complex transformations of the aorti...
Modeling Inherited Disorders of Post-Lanosterol Cholesterol Biosynthesis: From Animal Models to Patient-Derived Stem Cells.
Altered post-lanosterol cholesterol biosynthesis causes a heterogeneous group of rare inherited metabolic disorders, including Smith-Lemli-Opitz syndrome, desmosterolosis, lathosterolosis, and congeni...