Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala.
S, D., A, C., IS, A., GL, O., A, B.C., P, N.P., E, W., V, A., J, A., & D, D. (2026). Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala.. Journal of global health. https://doi.org/10.7189/jogh.16.04232
S D, A C, IS A, GL O, A BC, P NP, et al. Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala.. Journal of global health. 2026; doi: 10.7189/jogh.16.04232
S D, A C, IS A, et al. Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala.[J]. Journal of global health. 2026. DOI: 10.7189/jogh.16.04232.
@article{s2026,
author = {Duffy S and Chavez A and Arthur IS and Ortiz GL and Bermudez-Cañete A and Nuñez-Perez P and White E and Aguilar V and Aguirre J and Dang D},
title = {Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala.},
journal = {Journal of global health},
year = {2026},
doi = {10.7189/jogh.16.04232},
note = {PMID: 42533611},
}
TY - JOUR AU - Duffy S AU - Chavez A AU - Arthur IS AU - Ortiz GL AU - Bermudez-Cañete A AU - Nuñez-Perez P AU - White E AU - Aguilar V AU - Aguirre J AU - Dang D TI - Feasibility study of a novel mHealth clinical decision support application to enable community health workers to manage hypertension in rural Guatemala. T2 - Journal of global health PY - 2026 DO - 10.7189/jogh.16.04232 AN - PMID:42533611 ER -
BACKGROUND: Hypertension is a leading global cause of morbidity and mortality, especially in low- and middle-income countries, where low healthcare access limits diagnosis and treatment. Community health workers (CHWs) supported by mobile health (mHealth) clinical decision support (CDS) tools may help. This study evaluated the feasibility of CHW-led hypertension management using an mHealth CDS application in rural Guatemala. METHODS: We conducted a single-group feasibility study in San Lucas Tolimán, Guatemala. Trained CHWs assisted by a CommCare-based CDS application provided direct patient care. Application algorithms were based on World Health Organization guidelines and assisted with medication titration, lifestyle counselling, and physician consultation. Adults (≥18 years) with diagnosed hypertension were followed monthly for six months. The primary feasibility outcome was prescribing agreement between CHWs and supervising physicians with application of antihypertensive recommendations (minimum acceptable agreement was 90%). Primary clinical outcomes were changes in systolic (SBP) and diastolic (DBP) blood pressure. Secondary outcomes included retention, patient satisfaction, and safety. RESULTS: In total 32 participants were enrolled and 30 (93.8%) completed six-month follow-up, with 96.4% of possible visits completed. CHW-physician agreement with application recommendations was 98.9%. The median decrease in SBP was 7.5 mm Hg (95% confidence interval (CI) = 1.0, 12.0), and the mean decrease in DBP was 3.1 mm Hg (95% CI = 0.1, 6.1). The proportion of patients with controlled SBP (<140 mm Hg) increased from 66.7% to 76.7% (P = 0.505). A total of 11 application errors (5.0% of 217 visits) occurred, none of which resulted in adverse events. Only three patients experienced significant adverse events, none of which required hospitalisation. Patient satisfaction remained high. CONCLUSIONS: In this pilot, CHWs supported by an mHealth CDS application safely managed hypertension with high physician agreement, patient retention, and blood pressure improvement. These findings demonstrate the feasibility of CHW task-sharing hypertension management in low-resource settings and support evaluation of this approach in larger trials. REGISTRATION: ClinicalTrials.gov: NCT05479097.