Breaching the Blood-Brain Barrier: Evolving Strategies for Central Nervous System Disease in Adult Acute Lymphoblastic Leukemia.
PURPOSE OF REVIEW: Central nervous system (CNS) involvement in adult acute lymphoblastic leukemia (ALL) remains a critical determinant of treatment failure and long-term survival. This review provides...
Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations.
Acid-sensing ion channels (ASICs) are proton-gated members of the degenerin/epithelial sodium channel family that are emerging as multifaceted regulators of cardiovascular function. ASICs expressed in...
Refined Carbohydrate-Rich Diet Promotes Early Myocardial Dysfunction Associated with Adiponectin Reduction, Inflammation, and Impaired Ca(2+) Handling in Female Rats.
Introduction: Diets rich in refined carbohydrates are associated with cardiometabolic dysfunction, but the mechanisms linking metabolic disturbances to myocardial impairment in females remain unclear....
The Role of Malnutrition, Nutritional Deficiencies and Eating Disorders in Patients with Takotsubo Syndrome-Scoping Review.
OBJECTIVES: Takotsubo syndrome (TTS) is an acute, often reversible disorder of left ventricular systolic function, the pathophysiology of which is complex and still being studied. A growing body of cl...
Are Direct-Acting Antivirals Effective and Safe for Hepatitis C Patients with Arterial Hypertension? Evidence from a Large Retrospective Real-World Study.
Background/Objectives: Arterial hypertension (AH) and hepatitis C virus (HCV) infection are interlinked, with AH increasing the risk of severe liver disease and HCV contributing to cardiovascular issu...
Repurposing Heart Failure Therapies in Pulmonary Arterial Hypertension: Mechanistic Rationale, Translational Evidence, and Clinical Perspectives for SGLT2 Inhibitors and Mineralocorticoid Receptor Antagonists.
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening condition characterized by elevated pulmonary vascular resistance eventually causing right ventricular failure and premature...
Preoperative vascular parameters and proximal splenorenal shunt patency in pediatric extrahepatic portal vein thrombosis.
PURPOSE: Shunt thrombosis is an important complication after proximal splenorenal shunt (PSRS) in children with extrahepatic portal vein thrombosis (EHPVT). We evaluated whether preoperative vascular ...
Heparin combined with urokinase therapy for the treatment of acute portal vein thrombosis in children.
PURPOSE: Acute portal vein thrombosis (PVT) poses a significant threat to life, with mortality rates ranging from 20% to 50%. However, a clear consensus on the management of acute PVT in children is l...
[Dyspnea, pulmonary mosaic sign and pulmonary hypertension].
This case report presents a young female patient whose chief complaint was exertional dyspnea. Right heart catheterization confirmed severe pulmonary hypertension. Concurrently, chest CT showed atypic...
[Clinical characteristics of middle-age and elderly patients with active Takayasu arteritis disease].
Objective: To draw attention to the diagnosis of active Takayasu arteritis (TAK) in middle-aged and elderly patients and to analyze the clinical characteristics of this population. Methods: Clinical d...
Curcumin in Atherogenic Dyslipidemia: Linking Preclinical Mechanistic Insights to Clinical Outcomes.
Background/Objectives: Atherogenic dyslipidemia is a major cardiometabolic risk factor characterized by elevated circulating triglycerides (TGs), reduced HDL-C, and increased levels of atherogenic lip...
Association Between Serum Leucine and NT-proBNP Levels in Relation to Fragmented QRS: A Multiomic Analysis of the HOZUGAWA Cohort.
BACKGROUND/OBJECTIVES: Branched-chain amino acids (BCAAs) may play a protective role in the progression of heart failure; however, controversial results also exist. This study investigates the associa...
The Angiopoietin-like Protein (ANGPTL) Axis in Dyslipidemia: Mechanisms, Cardiovascular Risk, and Emerging Therapies.
PURPOSE OF REVIEW: The angiopoietin-like protein (ANGPTL) 3-4-8 axis has emerged as a central regulator of lipoprotein lipase and lipid metabolism. This review examines the mechanistic basis of ANGPTL...
The Neuroimmune Mechanisms Linking Smoking and Infection to Atherosclerosis: Chronic vs. Surge.
The pathogenesis of atherosclerosis has progressively shifted from a lipid-centric model to one that recognizes inflammation as the central driver. Smoking is a well-established chronic risk factor, w...
A systematic review of patient decision aids for hypertension.
BACKGROUND: Hypertension is a major cause of premature death and a modifiable risk factor for cardiovascular disease. Effective management includes both pharmacological treatment strategies, including...
Night shift work as a potential risk factor for hypertensive disorders of pregnancy: the Japan environment and children's study.
OBJECTIVE: This study aimed to clarify the relationship between the night shift work and hypertensive disorders of pregnancy (HDP). Moreover, we examined whether night shift work is associated with ea...
MiR-378a-3p Promotes Macrophage Polarization from M1 to M2 for Cardiac Repair after Infarction Via Trem1.
Acute myocardial infarction (AMI) triggers a robust inflammatory response in which macrophage polarization critically influences cardiac repair, yet the regulatory role of microRNAs remains largely un...
IGF2BP1 modulates ZDHHC5-mediated NLRP3 inflammasome activation to promote mitochondrial damage and foam cell formation of vascular smooth muscle cells.
BACKGROUND: Smooth muscle-derived foam cell formation is a key to atherosclerosis (AS) development. Mitochondrial damage is involved in AS pathogenesis S. Here, effects of ZDHHC5 on mitochondrial dama...
Post-viral myocarditis.
Myocarditis is an inflammatory disease of the myocardium characterized by complex histological, immunological and molecular changes occur that may ultimately lead to post-viral cardiomyopathy, a speci...
The mtROS-Mitophagy Axis: A Decisive Redox Hub Governing Cell Fate in Myocardial Ischemia-Reperfusion Injury.
The progression of myocardial ischemia-reperfusion injury (MIRI) is orchestrated by a decisive, bidirectional dialogue between mitochondrial reactive oxygen species (mtROS) and mitophagy. This review ...