Reevaluating the Use of Race/Ethnicity in the MESA Risk Score.
BACKGROUND: Cardiovascular disease risk scores are widespread in research and clinical settings. The MESA (Multi-Ethnic Study of Atherosclerosis) risk score estimates the 10-year risk of coronary hear...
Evaluation of a sleep sound analysis smartphone app for home obstructive sleep apnea screening among community-dwelling Chinese adults with hypertension.
PURPOSE: This study aimed to evaluate the validity and feasibility of home obstructive sleep apnea screening using a sleep sound analysis smartphone app compared to the STOP-BANG questionnaire (SBQ) a...
Yiqi Fumai Lyophilized Injection for Improving Exercise Tolerance in Chronic Heart Failure: Protocol for a Prospective Cohort Study.
BACKGROUND: High mortality and prevalence rates are hallmarks of chronic heart failure (CHF). Patients frequently have a much lower quality of life as a result of diminished exercise tolerance. Chines...
Tachycardia-induced cardiomyopathy: evolution of the concept and contemporary insights.
Tachycardia-induced cardiomyopathy (TIC) is a reversible form of myocardial dysfunction caused by sustained or recurrent tachyarrhythmias. Despite increasing recognition, its diagnosis and management ...
Non-catheter-adherent right atrial mural thrombus in a patient with systemic sclerosis undergoing hemodialysis: a case report.
Catheter-related right atrial thrombosis is a rare, potentially fatal complication of central venous catheterization. While most reported cases involve thrombi attached to the catheter tip or mobile i...
Glymphatic dysfunction associates with regional white matter hyperintensities and plasma amyloid-β burden across the Alzheimer's disease continuum.
BACKGROUND: Glymphatic system dysfunction has been increasingly implicated in Alzheimer's disease (AD), yet its relationships with cerebral small vessel disease (CSVD), plasma biomarkers, and cognitiv...
A Communicating Anomalous Vessel Between the Brachial and Radial Artery: A Cadaver Case Report.
BACKGROUND The arrangement of the arm vasculature is known to vary between individuals with a majority being clinically silent. In this report, we describe a rare arterial anomaly in which a branch ar...
Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance.
Excessive trabeculation has been considered the morphological hallmark of left ventricular non-compaction (LVNC), traditionally viewed as a primary cardiomyopathy resulting from an arrest in myocardia...
Sirtuin 1 deficiency mediates chronic kidney disease-induced inflammaging cardiovascular calcification.
Chronic kidney disease (CKD) markedly accelerates calcific aortic valve disease (CAVD), yet the underlying mechanisms and therapeutic targets remain poorly defined. Here, we integrate population-scale...
Neuropeptide signaling and the blood-brain barrier generate a persistent stress-induced internal state in Drosophila.
Although fear conditioning has elucidated cue-evoked acute fear responses, the mechanisms by which stress experiences induce generalized internal states linked to anxiety or phobia are poorly understo...
Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) variants in genes encoding the myosin heavy chain (MHC) (MYH7), myosin light chains (MYL2 and MYL3), and cardiac myosin binding protein-C (cMyBP-C, MYBPC3) lead to ca...
Chronic limb-threatening ischemia (CLTI) caused by infrapopliteal disease is a major therapeutic challenge, with percutaneous transluminal angioplasty (PTA) associated with high rates of restenosis an...
Kawasaki disease (KD) is an acute medium-size vasculitis that affects the coronary arteries. Untreated children can develop coronary artery aneurysms with a prevalence of ≈25%, but prompt treatment wi...
The clinical benefit of intensive LDL-C-lowering with evolocumab in patients with prior percutaneous coronary intervention (PCI) but without a prior myocardial infarction (MI) is not established.
Young athletes and adolescents with high cardiorespiratory fitness appear to have a higher risk of atrial fibrillation (AF), but the extent to which this reflects causal effects or shared genetic, beh...
There is interest in developing lipoprotein(a) [Lp(a)] lowering therapies. Cholesteryl ester transfer protein inhibitors lower Lp(a), however the effects of the selective inhibitor obicetrapib on Lp(a...
Weight loss and weight loss maintenance are prominent topics of discussion for clinicians and health professionals involved in treatment to reduce obesity and the risk of cardiovascular disease. Becau...
Lesion Morphology and Technical Success in Diabetic vs. Non-Diabetic Patients with Chronic Limb-Threatening Ischemia Undergoing Endovascular Treatment: A Retrospective Single-Center Study.
Background and Objectives: Chronic limb-threatening ischemia (CLTI) represents the most advanced stage of peripheral arterial disease and is associated with an increased risk of major amputation, part...
Low-Frequency Components of the Heart Sound Corresponding to the Fourth Heart Sound Phase, Assessed by Phonocardiography, Correlate with Early Variations in Echocardiographic Indices Related to Diastolic Function.
Background and Objectives: The fourth heart sound (S4) is a recognized marker of left ventricular (LV) diastolic dysfunction, suggesting a potential risk of congestive heart failure (CHF). However, lo...
Prevalence and Impact of Pulmonary Hypertension Associated with Arteriovenous Fistulas and Grafts in End-Stage Renal Disease: A Systematic Review and Meta-Analysis.
BACKGROUND/OBJECTIVES: Pulmonary hypertension (PH) is an increasingly recognized complication in patients with end-stage renal disease (ESRD) undergoing hemodialysis, particularly those utilizing arte...