Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.
M, F., MA, S., M, W., JC, M., P, F., C, T., AD, H., & G, C. (2026). Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.. Journal of clinical hypertension (Greenwich, Conn.). https://doi.org/10.1111/jch.70312
M F, MA S, M W, JC M, P F, C T, et al. Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.. Journal of clinical hypertension (Greenwich, Conn.). 2026; doi: 10.1111/jch.70312
M F, MA S, M W, et al. Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.[J]. Journal of clinical hypertension (Greenwich, Conn.). 2026. DOI: 10.1111/jch.70312.
@article{m2026,
author = {Fornasiero M and Stanley MA and Webber M and Moon JC and Friberg P and Topriceanu C and Hughes AD and Captur G},
title = {Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.},
journal = {Journal of clinical hypertension (Greenwich, Conn.)},
year = {2026},
doi = {10.1111/jch.70312},
note = {PMID: 42295287},
}
TY - JOUR AU - Fornasiero M AU - Stanley MA AU - Webber M AU - Moon JC AU - Friberg P AU - Topriceanu C AU - Hughes AD AU - Captur G TI - Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age. T2 - Journal of clinical hypertension (Greenwich, Conn.) PY - 2026 DO - 10.1111/jch.70312 AN - PMID:42295287 ER -
Loss of the normal heart rate variability (HRV) predicts death. This study investigated the association between carotid arterial strain (CAS) and HRV in an older age population-based cohort. We hypothesized that impaired arterial compliance and increased vascular stiffness could inhibit the baroreceptor reflex, resulting in cardiac autonomic dysfunction and loss of the normal HRV. Participants (60-64 years) were from the 1946 Medical Research Council, National Survey of Health and Development, British birth cohort. Carotid intima media thickness (cIMT) and CAS (exposures) were measured by ultrasound, and time- and frequency-domain HRV indices (outcomes) by a resting 5-min 12-lead tachogram. Generalized linear models were used, adjusted for relevant clinic-demographic confounders and subjected to sensitivity analysis in which we re-analyzed associations after additional adjustment for cIMT and after removing participants with known cardiovascular disease. Eight hundred and ninety-six participants were included. On univariate analysis, CAS was associated with HRV markers: standard deviation of normal-to-normal beats (SDNN), root mean square of successive differences (RMSDD), HRV triangular index, high- and low-frequency (H/LF) normalized high-frequency power (all p < 0.05). Associations persisted in fully confounder-adjusted models: SDNN β = 0.52 [confidence interval: 0.2, 0.8] p < 0.001; RMSDD β = 0.59 [0.3, 0.9], p < 0.001; HRV triangular index β = -0.34 [-0.5, -0.1], p < 0.001; HF power β = 8.33 [2.2, 14.4], p = 0.007; LF power b = 8.47 [1.0, 15.9], p = 0.026; normalized HF power β = 0.55 [0.2, 0.9], p = 0.006. Key associations persisted in the sensitivity analysis. In conclusion, regardless of carotid atherosclerotic vascular disease (indicated by cIMT), hypertension, or stroke, our results demonstrated that carotid stiffening in older age associates with a loss of HRV, potentially through an impaired baroreceptor response.