Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients.
S, K., Y, B., AM, J., D, W., A, V., R, R., & MJ, S. (2026). Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients.. Comprehensive Physiology. https://doi.org/10.1002/cph4.70194
S K, Y B, AM J, D W, A V, R R, et al. Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients.. Comprehensive Physiology. 2026; doi: 10.1002/cph4.70194
S K, Y B, AM J, et al. Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients.[J]. Comprehensive Physiology. 2026. DOI: 10.1002/cph4.70194.
@article{s2026,
author = {Kadosh S and Baidats Y and Jones AM and Wilkerson D and Velner A and Reuveny R and Segel MJ},
title = {Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients.},
journal = {Comprehensive Physiology},
year = {2026},
doi = {10.1002/cph4.70194},
note = {PMID: 42281222},
}
TY - JOUR AU - Kadosh S AU - Baidats Y AU - Jones AM AU - Wilkerson D AU - Velner A AU - Reuveny R AU - Segel MJ TI - Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients. T2 - Comprehensive Physiology PY - 2026 DO - 10.1002/cph4.70194 AN - PMID:42281222 ER -
AIM: We studied the effect of O2 supplementation on physiological responses to exercise in patients with pulmonary vascular disease. METHODS: Six patients with pulmonary arterial hypertension (PAH), four patients with chronic thromboembolic pulmonary hypertension (CTEPH) (age 54 ± 17 years; 8 females) and 13 healthy individuals (age 50 ± 17 years; 5 females) were tested. PAH/CTEPH was defined hemodynamically by mPAP > 20 mmHg and PVR > 3 WU. Patients performed symptom-limited cardiopulmonary exercise tests, and constant work-rate tests (CWRTs) at 80% of the work-rate (WR) at the gas exchange threshold (GET). Tests breathing room air (RA, 21% O2) were compared to tests performed breathing 30% O2. Oxygen-uptake (V̇O2) kinetics were calculated from the CWRT results. RESULTS: In the PAH/CTEPH group, peak WR, peak V̇O2 and V̇O2 at the GET improved significantly when breathing 30% O2 compared to RA (mean ± SD 85 ± 26 vs. 77 ± 25 W, 18.3 ± 5.8 vs. 15.6 ± 5.7 mL/kg/min and 764 ± 181 vs. 685 ± 154 mL/min; p = 0.011, p = 0.015 and p = 0.012, respectively). Peak V̇O2/HR was higher with 30% O2 compared with RA (8.8 ± 2.2 vs. 7.7 ± 1.8 mL/beat, p = 0.021). The time constant (tau) of V̇O2 kinetics was faster in PAH/CTEPH patients while breathing 30% O2 compared to RA (36 ± 4 vs. 43 ± 6 s, p = 0.009). In healthy individuals there was no improvement in V̇O2 kinetics while breathing 30% O2 compared to RA (tau 35 ± 6 vs. 35 ± 6 s, p = 0.916). CONCLUSION: A clinically applicable level of O2 supplementation (30%) improved maximal and aerobic exercise capacity and V̇O2 kinetics in PAH/CTEPH patients. O2 supplementation may be considered to support exercise training in PAH/CTEPH patients.