Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.
Z, C., Y, W., & X, H. (2026). Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.. Metabolic brain disease. https://doi.org/10.1007/s11011-026-01899-5
Z C, Y W, X H. Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.. Metabolic brain disease. 2026; doi: 10.1007/s11011-026-01899-5
Z C, Y W, X H. Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.[J]. Metabolic brain disease. 2026. DOI: 10.1007/s11011-026-01899-5.
@article{z2026,
author = {Cao Z and Wang Y and Han X},
title = {Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.},
journal = {Metabolic brain disease},
year = {2026},
doi = {10.1007/s11011-026-01899-5},
note = {PMID: 42301345},
}
TY - JOUR AU - Cao Z AU - Wang Y AU - Han X TI - Hippocampal cytopathology orchestrates post-septic cognitive dysfunction. T2 - Metabolic brain disease PY - 2026 DO - 10.1007/s11011-026-01899-5 AN - PMID:42301345 ER -
Cognitive dysfunction induced by sepsis is a common clinical disease. The hippocampus is one of the brain regions most vulnerable to sepsis. However, the correlations between sepsis-mediated neural cell types, pathological characteristics, and molecular mechanisms in hippocampal tissue and brain cognitive damage remain incompletely understood. This review summarizes: (1) the pathological features and mechanisms of blood-brain barrier disruption in sepsis; (2) the pathological effects of sepsis on different types of hippocampal neurons and the underlying molecular mechanisms; (3) the activation of peripheral inflammatory cells and central resident microglia and their roles in neuronal and oligodendrocyte death, as well as synaptic pruning, along with the associated mechanisms; and (4) the activation of sepsis-induced reactive astrocytes and their impact on cognitive function. Finally, this article analyzes potential therapeutic strategies for sepsis-associated brain cognitive dysfunction.