Association between the expression levels of miR-17-5p/IGFBP5 and exercise-induced physiological cardiac hypertrophy.
YZ, G., H, W., HJ, H., DY, L., & H, L. (2026). Association between the expression levels of miR-17-5p/IGFBP5 and exercise-induced physiological cardiac hypertrophy.. General physiology and biophysics. https://doi.org/10.4149/gpb_2026002
YZ G, H W, HJ H, DY L, H L. Association between the expression levels of miR-17-5p/IGFBP5 and exercise-induced physiological cardiac hypertrophy.. General physiology and biophysics. 2026; doi: 10.4149/gpb_2026002
YZ G, H W, HJ H, et al. Association between the expression levels of miR-17-5p/IGFBP5 and exercise-induced physiological cardiac hypertrophy.[J]. General physiology and biophysics. 2026. DOI: 10.4149/gpb_2026002.
@article{yz2026,
author = {Guan YZ and Wang H and Huang HJ and Liang DY and Liu H},
title = {Association between the expression levels of miR-17-5p/IGFBP5 and exercise-induced physiological cardiac hypertrophy.},
journal = {General physiology and biophysics},
year = {2026},
doi = {10.4149/gpb_2026002},
note = {PMID: 42305061},
}
TY - JOUR AU - Guan YZ AU - Wang H AU - Huang HJ AU - Liang DY AU - Liu H TI - Association between the expression levels of miR-17-5p/IGFBP5 and exercise-induced physiological cardiac hypertrophy. T2 - General physiology and biophysics PY - 2026 DO - 10.4149/gpb_2026002 AN - PMID:42305061 ER -
Pathological cardiac hypertrophy (PaCH) leads to heart failure, whereas exercise-induced physiological cardiac hypertrophy (PhCH) represents a benign adaptive response, and counteracts PaCH. Here, we investigated the association of miR-17-5p and IGFBP5 expressions with PhCH through a PhCH group (five mice with 21-days swimming exercise) and healthy controls (n = 5). The PhCH group showed higher body weight (BW), heart weight (HW), HW/BW ratio, ventricular septal thickness, left-ventricular end-diastolic diameter, and left-ventricular end-systolic diameter than control group (p < 0.05 for all). The IGFBP5 expression was significantly reduced, whereas miR-17-5p expression was significantly elevated in PhCH group (p < 0.05). Dual-luciferase assays validated the direct binding of miR-17-5p with IGFBP5. Wheat germ agglutinin staining revealed enlarged cardiomyocytes of PhCH group, while Masson staining disclosed no increase of fibrosis. The reduction of IGFBP5 and elevation of miR-17-5p are associated with PhCH, suggesting their potentials for further researches in myocardial hypertrophy.