Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.
Malak, B., Bachir, M.M., Hajar, E.O., Badre, E.B., & Zainab, R. (2026). Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.. Eur Heart J Case Rep. https://doi.org/10.1093/ehjcr/ytag227
Malak B, Bachir MM, Hajar EO, Badre EB, Zainab R. Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.. Eur Heart J Case Rep. 2026; doi: 10.1093/ehjcr/ytag227
Malak B, Bachir MM, Hajar EO, et al. Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.[J]. Eur Heart J Case Rep. 2026. DOI: 10.1093/ehjcr/ytag227.
@article{malak2026,
author = {Benabdellah Malak and Mesfioui Mohammed Bachir and El Ouartassi Hajar and El Boussaadani Badre and Raissuni Zainab},
title = {Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.},
journal = {Eur Heart J Case Rep},
year = {2026},
doi = {10.1093/ehjcr/ytag227},
note = {PMID: 41993942},
}
TY - JOUR AU - Benabdellah Malak AU - Mesfioui Mohammed Bachir AU - El Ouartassi Hajar AU - El Boussaadani Badre AU - Raissuni Zainab TI - Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report. T2 - Eur Heart J Case Rep PY - 2026 DO - 10.1093/ehjcr/ytag227 AN - PMID:41993942 ER -
Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder characterized by an elevated plasma concentration of low-density lipoprotein cholesterol (LDL-C) starting at birth and a significantly increased risk of premature atherosclerotic cardiovascular disease. We report the case of a 16-year-old female patient, with no known consanguinity, presented to our cardiology department for anginal chest pain on exertion associated with headaches. She presented with characteristic morphological features of FH. Her lipid profile revealed extremely high LDL-C levels (706 mg/dL) and such extensive arterial and cutaneous involvement. This case underscores the importance of recognizing xanthomas and their association with an increased risk of coronary atherosclerosis.