Qualitative and Quantitative Assessment of Restored Capillary Perfusion on OCT Angiography in Diabetic Macular Ischemia.
M, Y., T, M., K, I., Y, M., Y, I., & A, T. (2026). Qualitative and Quantitative Assessment of Restored Capillary Perfusion on OCT Angiography in Diabetic Macular Ischemia.. Translational vision science & technology. https://doi.org/10.1167/tvst.15.6.20
M Y, T M, K I, Y M, Y I, A T. Qualitative and Quantitative Assessment of Restored Capillary Perfusion on OCT Angiography in Diabetic Macular Ischemia.. Translational vision science & technology. 2026; doi: 10.1167/tvst.15.6.20
M Y, T M, K I, et al. Qualitative and Quantitative Assessment of Restored Capillary Perfusion on OCT Angiography in Diabetic Macular Ischemia.[J]. Translational vision science & technology. 2026. DOI: 10.1167/tvst.15.6.20.
@article{m2026,
author = {Yoshida M and Murakami T and Ishihara K and Mori Y and Iga Y and Tsujikawa A},
title = {Qualitative and Quantitative Assessment of Restored Capillary Perfusion on OCT Angiography in Diabetic Macular Ischemia.},
journal = {Translational vision science & technology},
year = {2026},
doi = {10.1167/tvst.15.6.20},
note = {PMID: 42307175},
}
TY - JOUR AU - Yoshida M AU - Murakami T AU - Ishihara K AU - Mori Y AU - Iga Y AU - Tsujikawa A TI - Qualitative and Quantitative Assessment of Restored Capillary Perfusion on OCT Angiography in Diabetic Macular Ischemia. T2 - Translational vision science & technology PY - 2026 DO - 10.1167/tvst.15.6.20 AN - PMID:42307175 ER -
PURPOSE: The purpose of this study was to investigate characteristics of restored capillary perfusion on optical coherence tomography angiography (OCTA) in diabetic retinopathy (DR). METHODS: We prospectively obtained OCTA images from 106 eyes of 106 patients with DR and analyzed them within a 2.5-mm-diameter circle. The area was divided into 15 × 15-pixel squares; those without vascular edge signals were defined as nonperfusion squares (NPSs) at baseline and 3 years after image registration. Qualitative assessment identified OCTA findings representing restored perfusion: newly developed uniform-caliber vessels ("rod-like vessels"), vessels with distal enlargement ("bulb sign"), loop-forming vessels ("loop vessel"), and "vessel reappearance" suggestive of reperfusion. RESULTS: In the superficial layer, eyes with advanced diabetic macular ischemia (DMI) showed NPS reduction in the central subfield more frequently than those with mild DMI (P < 0.001). Baseline NPS counts were negatively correlated with 3-year NPS changes in the central sector of the superficial and deep layers (P < 0.05). In the deep layer, NPS reduction in the parafoveal sectors was observed more frequently in eyes with advanced DMI (P < 0.05). Qualitative assessment showed rod-like vessels, bulb signs, loop vessels, and vessel reappearance in 81, 75, 11, and 93 eyes, respectively. Rod-like vessels and bulb signs were more frequently observed outside the foveal avascular zone (FAZ) than within it in the superficial layer (P < 0.001 for both comparisons). CONCLUSIONS: Quantitative and qualitative analyses demonstrated restored capillary perfusion on OCTA in some eyes with DMI, suggesting revascularization and reperfusion. TRANSLATIONAL RELEVANCE: Advanced DMI exhibits both progressive capillary nonperfusion and restored capillary perfusion on OCTA.