A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial.
Giulia, M., Giorgia, P., Giuseppe, M., Rachele, L.S., Giuseppe, D.S., Luca, G.F., Domenico, T., Laura, T.T., Maddalena, A., Rossella, G., Maria, M., Rebecca, N., Elia, I., Nicolò, P., Ambra, B., Andrea, C., Nicola, D.S., Silvia, L., Sara, F., . . . Diego, A. (2026). A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial.. Eur Heart J. https://doi.org/10.1093/eurheartj/ehag255
Giulia M, Giorgia P, Giuseppe M, Rachele LS, Giuseppe DS, Luca GF, et al. A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial.. Eur Heart J. 2026; doi: 10.1093/eurheartj/ehag255
Giulia M, Giorgia P, Giuseppe M, et al. A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial.[J]. Eur Heart J. 2026. DOI: 10.1093/eurheartj/ehag255.
@article{giulia2026,
author = {Magnani Giulia and Paoli Giorgia and Maglietta Giuseppe and La Sala Rachele and De Stefano Giuseppe and Gurgoglione Filippo Luca and Tuttolomondo Domenico and Torlai Triglia Laura and Ardissino Maddalena and Giacalone Rossella and Mattioli Maria and Navacchi Rebecca and Indrigo Elia and Pasini Nicolò and Borghi Ambra and Caraffini Andrea and De Santis Nicola and Lazzarelli Silvia and Fusco Sara and Ritacco Maria Luisa and Guerra Anna Francesca and Ricci Monica and Zobbi Gianni and Dall'Ospedale Valeria and Giordano Rosanna and Notarangelo Maria Francesca and Solinas Emilia and Tondi Stefano and Navazio Alessandro and Tortorella Giovanni and Aschieri Daniela and Patrizi Giampiero and Caminiti Caterina and Niccoli Giampaolo and Ardissino Diego},
title = {A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial.},
journal = {Eur Heart J},
year = {2026},
doi = {10.1093/eurheartj/ehag255},
note = {PMID: 42085325},
}
TY - JOUR AU - Magnani Giulia AU - Paoli Giorgia AU - Maglietta Giuseppe AU - La Sala Rachele AU - De Stefano Giuseppe AU - Gurgoglione Filippo Luca AU - Tuttolomondo Domenico AU - Torlai Triglia Laura AU - Ardissino Maddalena AU - Giacalone Rossella AU - Mattioli Maria AU - Navacchi Rebecca AU - Indrigo Elia AU - Pasini Nicolò AU - Borghi Ambra AU - Caraffini Andrea AU - De Santis Nicola AU - Lazzarelli Silvia AU - Fusco Sara AU - Ritacco Maria Luisa AU - Guerra Anna Francesca AU - Ricci Monica AU - Zobbi Gianni AU - Dall'Ospedale Valeria AU - Giordano Rosanna AU - Notarangelo Maria Francesca AU - Solinas Emilia AU - Tondi Stefano AU - Navazio Alessandro AU - Tortorella Giovanni AU - Aschieri Daniela AU - Patrizi Giampiero AU - Caminiti Caterina AU - Niccoli Giampaolo AU - Ardissino Diego TI - A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial. T2 - Eur Heart J PY - 2026 DO - 10.1093/eurheartj/ehag255 AN - PMID:42085325 ER -
There is a lack of long-term outcome data supporting the role of nurses in cardiovascular (CV) risk management. The ALLEPRE [ALLiance for sEcondary PREvention after an acute coronary syndrome (ACS)] trial was a pragmatic, randomized, multicentre, interventional trial comparing the efficacy of a nurse-coordinated prevention program (NCPP) with standard of care (SOC). The NCPP patients attended nine individual educational sessions over four years at which a centrally trained nurse provided counselling aimed at identifying CV risk factors and encouraging healthier lifestyles and medication adherence; the SOC patients followed the standard practices of their hospitals. The trial's primary endpoint was the composite of CV death, non-fatal myocardial infarction (MI), and non-fatal stroke (MACE). A total of 2057 ACS patients were randomized 1:1 to the NCCP (n=1031) or SOC group (n=1026). In comparison with SOC, the NCPP significantly reduced MACE [16.2% vs 22.6%; hazard ratio (HR) 0.70; 95% confidence interval (CI) 0.57-0.85; P-value <0.001], a benefit mainly driven by a reduction in non-fatal MI (9.3% vs 15.2%; HR 0.60; 95% CI 0.46-0.77; P-value=0.0001). The occurrence of the pre-specified secondary outcome of MACE plus ischaemia-driven revascularization was significantly reduced (HR 0.77, 95% CI 0.64-0.92; P-value= 0.005). Exercise frequency (P<0.0001), body weight control (P=0.003), and medication adherence (P<0.001) improved more in the NCPP group. The NCPP significantly reduced long-term MACE, improved physical activity, body weight control, and pharmacotherapy adherence in post-hospitalization ACS patients. Including an NCPP in healthcare provision may contribute to the successful implementation of secondary prevention strategies.