Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).
X, W., Q, T., J, X., Y, Y., H, H., X, T., & W, W. (2026). Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).. Molecular medicine reports. https://doi.org/10.3892/mmr.2026.13942
X W, Q T, J X, Y Y, H H, X T, et al. Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).. Molecular medicine reports. 2026; doi: 10.3892/mmr.2026.13942
X W, Q T, J X, et al. Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).[J]. Molecular medicine reports. 2026. DOI: 10.3892/mmr.2026.13942.
@article{x2026,
author = {Wang X and Tan Q and Xu J and Yang Y and Huang H and Teng X and Wu W},
title = {Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).},
journal = {Molecular medicine reports},
year = {2026},
doi = {10.3892/mmr.2026.13942},
note = {PMID: 42318957},
}
TY - JOUR AU - Wang X AU - Tan Q AU - Xu J AU - Yang Y AU - Huang H AU - Teng X AU - Wu W TI - Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review). T2 - Molecular medicine reports PY - 2026 DO - 10.3892/mmr.2026.13942 AN - PMID:42318957 ER -
Thoracic aortic aneurysm and dissection (TAAD) is a life‑threatening disease with an insidious onset and a largely elusive pathogenesis. Hereditary TAAD (HTAD) can be classified into syndromic forms, including Marfan syndrome, Loeys‑Dietz syndrome and vascular Ehlers‑Danlos syndrome and non‑syndromic forms, including familial TAAD and bicuspid aortic valve‑associated TAAD. Current evidence suggests that HTAD development shares several core mechanisms, including extracellular matrix disruption, dysregulated transforming growth factor‑β signaling, vascular smooth muscle cell dysfunction and, in the case of bicuspid aortic valve, abnormal hemodynamic stress. The present review summarizes the major genes and molecular pathways involved in HTAD and discusses their contributions to disease progression. Elucidating the underlying mechanisms associated with HTAD may facilitate risk assessment and the development of targeted therapies.