[Gene and Cell Technologies for Treatment of Brain Malignancies].
II, A., KV, K., AV, G., MG, S., AA, R., & VV, S. (2026). [Gene and Cell Technologies for Treatment of Brain Malignancies].. Molekuliarnaia biologiia. https://doi.org/10.7868/S3034555326020018
II A, KV K, AV G, MG S, AA R, VV S. [Gene and Cell Technologies for Treatment of Brain Malignancies].. Molekuliarnaia biologiia. 2026; doi: 10.7868/S3034555326020018
II A, KV K, AV G, et al. [Gene and Cell Technologies for Treatment of Brain Malignancies].[J]. Molekuliarnaia biologiia. 2026. DOI: 10.7868/S3034555326020018.
@article{ii2026,
author = {Abdrakhmanova II and Kitaeva KV and Gorodilova AV and Saidgaraeva MG and Rizvanov AA and Solovyeva VV},
title = {[Gene and Cell Technologies for Treatment of Brain Malignancies].},
journal = {Molekuliarnaia biologiia},
year = {2026},
doi = {10.7868/S3034555326020018},
note = {PMID: 42227121},
}
TY - JOUR AU - Abdrakhmanova II AU - Kitaeva KV AU - Gorodilova AV AU - Saidgaraeva MG AU - Rizvanov AA AU - Solovyeva VV TI - [Gene and Cell Technologies for Treatment of Brain Malignancies]. T2 - Molekuliarnaia biologiia PY - 2026 DO - 10.7868/S3034555326020018 AN - PMID:42227121 ER -
Brain malignancies, such as glioblastoma, remain one of the most aggressive and difficult-to-treat cancers because of their heterogeneity, invasive growth, and resistance to conventional therapy. Significant recent progress in the treatment of these diseases has been associated with the development of gene and cell technologies, which open up new possibilities for targeted therapy, immunotherapy, and personalized approaches. The review systematically summarizes the data on current treatment strategies, including gene therapy, cell therapy, and combined approaches. Particular attention is paid to preclinical and clinical studies, as well as the prospects for overcoming major limitations, such as the blood-brain barrier, the immunosuppressive tumor microenvironment, and toxicity. Analysis of the literature demonstrates that integration of gene and cell technologies could provide a basis for developing effective treatments aimed at improving the survival of patients with central nervous system tumors.