Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.
ABA, d.S.A., AO, M., DF, d.S., JDC, D., ED, H., MFM, d.S.S., & H, S.C. (2026). Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.. FASEB journal : official publication of the Federation of American Societies for Experimental Biolog. https://doi.org/10.1096/fj.202600884RR
ABA dSA, AO M, DF dS, JDC D, ED H, MFM dSS, et al. Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.. FASEB journal : official publication of the Federation of American Societies for Experimental Biolog. 2026; doi: 10.1096/fj.202600884RR
ABA dSA, AO M, DF dS, et al. Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.[J]. FASEB journal : official publication of the Federation of American Societies for Experimental Biolog. 2026. DOI: 10.1096/fj.202600884RR.
@article{aba2026,
author = {da Silva-Alencar ABA and Matos AO and de Sousa DF and Dietz JDC and Hottz ED and da Silva-Sales MFM and Sales-Campos H},
title = {Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.},
journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biolog},
year = {2026},
doi = {10.1096/fj.202600884RR},
note = {PMID: 42328715},
}
TY - JOUR AU - da Silva-Alencar ABA AU - Matos AO AU - de Sousa DF AU - Dietz JDC AU - Hottz ED AU - da Silva-Sales MFM AU - Sales-Campos H TI - Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue. T2 - FASEB journal : official publication of the Federation of American Societies for Experimental Biolog PY - 2026 DO - 10.1096/fj.202600884RR AN - PMID:42328715 ER -
Dengue is an arboviral disease with major global public health impact. Its pathophysiology involves complex interactions between the virus and the host, including the immune response and the vascular endothelium. In this context, platelets play roles beyond hemostasis, acting as key immunomodulatory cells involved in inflammation and the regulation of vascular permeability. Therefore, this review summarizes and discusses the so called classic and non-classic platelet-related and endothelial biomarkers described in dengue virus infection. Classical biomarkers include P-selectin (CD62P), PF4/CXCL4, RANTES/CCL5, CD40L, IL-1β, VEGF, integrin αIIbβ3, CD63, and platelet extracellular vesicles, all supported by broad experimental and clinical evidence. Non-classical or emerging biomarkers include TLT-1, TREM-1/sTREM-1, angiopoietins (Ang-1/Ang-2), serotonin, ferritin, dengue virus envelope domain III (EIII), and soluble endothelial molecules such as IL-1RA, sCD163, SDC-1, sVCAM-1, IL-8, and IP-10. Alone or in combination, these markers can be used/explored as prognostic tools and/or as therapeutic targets. Finally, integrating multimarker panels encompassing hemostatic, inflammatory, and endothelial pathways may improve prognostic stratification. This approach could support targeted interventions and help reduce complications such as thrombocytopenia, plasma leakage, and dengue shock.