Age-Related Concentric Remodeling and Sex-Dependent Dimensional Variation in Left Ventricular Geometry: A Cardiac Magnetic Resonance Study.

摘要

BACKGROUND/OBJECTIVES: Left ventricular (LV) geometry reflects structural adaptation to aging and biological sex. While cardiac magnetic resonance (CMR) provides precise morphologic assessment, most prior studies have focused on volumetric and mass-based parameters rather than routinely reported linear indices. This study aimed to evaluate the influence of age and sex on LV geometry using wall thickness, LV end-diastolic diameter (LVEDD), and proportional indices derived from standard CMR reports. METHODS: In this retrospective cross-sectional study, 95 adult patients who underwent clinically indicated CMR were included. LV wall thickness, LVEDD, relative wall thickness (RWT), and wall thickness-to- LVEDD ratio (WT/LVEDD) were recorded. Participants were stratified by sex and age groups (18-40, 41-60, >60 years). Group comparisons, correlation analysis, multivariable linear regression, logistic regression, and Age × Sex interaction testing were performed to evaluate independent associated parameters of LV morphology and concentric remodeling. RESULTS: The mean age was 34.94 ± 16.00 years; 60.0% were male. Males had significantly larger LVED (43.12 ± 6.83 mm vs. 39.76 ± 6.11 mm, p = 0.014) and greater wall thickness measurements (p < 0.05 for septal and posterior wall thickness). Age showed a significant positive correlation with mean LV wall thickness (r = 0.275, p = 0.007) and WT/LVEDD ratio (r = 0.241, p = 0.019), but not with LVEDD (p = 0.414). In multivariable analysis, male sex was independently associated with larger LVED (B = 3.345, p = 0.017), whereas age was independently associated with WT/LVEDD ratio (B = 0.0018, p = 0.019). Logistic regression demonstrated that age independently increased the odds of concentric remodeling (OR = 1.041 per year, 95% CI: 1.011-1.072, p = 0.006). No significant Age × Sex interaction was observed. CONCLUSIONS: Advancing age was independently associated with proportional LV geometric remodeling, whereas male sex primarily influenced absolute ventricular dimensions. Routine CMR report-derived linear measurements were sufficient to detect these distinct structural patterns. These findings highlighted the feasibility of using standardized morphologic indices in daily clinical practice to identify early age-related concentric remodeling.