Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy.
EV, L., GV, B., AS, A., EA, C., DV, B., MA, S., RS, P., KA, S., YV, K., & SN, B. (2026). Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy.. Marine drugs. https://doi.org/10.3390/md24060193
EV L, GV B, AS A, EA C, DV B, MA S, et al. Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy.. Marine drugs. 2026; doi: 10.3390/md24060193
EV L, GV B, AS A, et al. Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy.[J]. Marine drugs. 2026. DOI: 10.3390/md24060193.
@article{ev2026,
author = {Leshchenko EV and Borkunov GV and Antonov AS and Chingizova EA and Berdyshev DV and Solovova MA and Popov RS and Sayankina KA and Khudyakova YV and Baldaev SN},
title = {Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy.},
journal = {Marine drugs},
year = {2026},
doi = {10.3390/md24060193},
note = {PMID: 42346779},
}
TY - JOUR AU - Leshchenko EV AU - Borkunov GV AU - Antonov AS AU - Chingizova EA AU - Berdyshev DV AU - Solovova MA AU - Popov RS AU - Sayankina KA AU - Khudyakova YV AU - Baldaev SN TI - Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy. T2 - Marine drugs PY - 2026 DO - 10.3390/md24060193 AN - PMID:42346779 ER -
Thirteen new decaline polyketides, namely, zosteropenillines T-W (1-4), 8-hydroxypallidopenilline A (5), 13-epi-zosteropenilline P (6), 11-epi-zosteropenilline N (7), 15-hydroxyzosteropenilline M (8), 8-hydroxyzosteropenilline M (9), 11-epi-zosteropenilline M (10), and zosteropenillines X-Z (11-13), along with 17 known related compounds (14-30) were isolated from the ethyl acetate extract of the marine-derived fungus Penicillium yezoense KMM 4679 cultivated on MgCl2-containing nutrient medium. The structures of the isolated compounds were established based on spectroscopic methods. The absolute configurations of zosteropenillines T (1) and V (3) were determined using time-dependent density functional theory (TD-DFT) calculations of the ECD spectra. X-ray diffraction analysis data were obtained for the known zosteropenilline S (28). A biogenetic pathway for 1-13 was proposed. The effects of the compounds on Staphylococcus aureus and Candida albicans growth and biofilm formation were observed. Zosteropenillines U (2), Y (12) and Z (13) with higher activity against C. albicans biofilms were nontoxic for normal cardiomyocyte H9c2 cells, making them promising anti-candidal agents. Moreover, zosteropenillines U and Y demonstrated cardioprotective effects in acute ischemia/reperfusion and CoCl2-mimicking hypoxia in vitro models.