The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.
C, S., T, C., Y, H., P, Y., Y, Z., & Y, Y. (2026). The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.. Translational vision science & technology. https://doi.org/10.1167/tvst.15.6.36
C S, T C, Y H, P Y, Y Z, Y Y. The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.. Translational vision science & technology. 2026; doi: 10.1167/tvst.15.6.36
C S, T C, Y H, et al. The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.[J]. Translational vision science & technology. 2026. DOI: 10.1167/tvst.15.6.36.
@article{c2026,
author = {Sun C and Chen T and Huang Y and Yang P and Zhou Y and Yuan Y},
title = {The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.},
journal = {Translational vision science & technology},
year = {2026},
doi = {10.1167/tvst.15.6.36},
note = {PMID: 42370635},
}
TY - JOUR AU - Sun C AU - Chen T AU - Huang Y AU - Yang P AU - Zhou Y AU - Yuan Y TI - The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes. T2 - Translational vision science & technology PY - 2026 DO - 10.1167/tvst.15.6.36 AN - PMID:42370635 ER -
PURPOSE: The purpose of this study was to investigate the effect of myopia on the optic disc morphology and retinal vascular geometry in anisometropic eyes. METHODS: This self-controlled study included 49 subjects with bilateral myopic anisometropia ≥2.0 diopters (D). Computer-assisted programs were used to measure optic disc morphology (disc diameter, cup‑to‑disc ratio, and ovality index) and retinal vascular geometry (central retinal vascular caliber, fractal dimension [FD], tortuosity, and branching parameters). Paired-samples t-tests assessed interocular parameter differences; independent-samples t-tests compared these interocular differences between anisometropia subgroups (<4 D vs. ≥4 D). Scatter plots and linear regression were used to analyze the correlation between interocular parameter differences and anisometropia severity. RESULTS: More myopic eyes showed significantly smaller optic disc horizontal diameters (P < 0.001), lower cup-to-disc ratio (P = 0.004), and greater ovality index (P < 0.001), as well as reduced arteriolar FD (P = 0.038) and venular FD (P = 0.023). The interocular differences in arteriolar FD (P < 0.001), angular asymmetry (P = 0.031), asymmetry ratio (P = 0.023), and junctional exponent deviation (JED) (P = 0.011) differed significantly between the two anisometropia subgroups. Increasing anisometropia was associated with greater interocular differences in arteriolar FD (P = 0.005) and venular FD (P = 0.005), and with a more negative interocular difference in arteriolar JED (P = 0.028). CONCLUSIONS: In myopic anisometropia, the more myopic eye has smaller and more tilted optic discs and a lower FD; interocular differences in FD and JED correlate with anisometropia degree. TRANSLATIONAL RELEVANCE: These findings enhance understanding of optic disc and retinal vascular changes in the myopic fundus.