Insights into Matrix Metalloproteinase-2 Genotypes, Smoking, Alcohol Drinking, Hypertension and Renal Cell Carcinoma in Taiwan.
SY, C., HW, T., BR, W., YC, Y., JC, C., CW, T., DT, B., & WS, C. (2026). Insights into Matrix Metalloproteinase-2 Genotypes, Smoking, Alcohol Drinking, Hypertension and Renal Cell Carcinoma in Taiwan.. Anticancer research. https://doi.org/10.21873/anticanres.18240
SY C, HW T, BR W, YC Y, JC C, CW T, et al. Insights into Matrix Metalloproteinase-2 Genotypes, Smoking, Alcohol Drinking, Hypertension and Renal Cell Carcinoma in Taiwan.. Anticancer research. 2026; doi: 10.21873/anticanres.18240
SY C, HW T, BR W, et al. Insights into Matrix Metalloproteinase-2 Genotypes, Smoking, Alcohol Drinking, Hypertension and Renal Cell Carcinoma in Taiwan.[J]. Anticancer research. 2026. DOI: 10.21873/anticanres.18240.
@article{sy2026,
author = {Chang SY and Tsai HW and Wang BR and Yang YC and Chen JC and Tsai CW and Bau DT and Chang WS},
title = {Insights into Matrix Metalloproteinase-2 Genotypes, Smoking, Alcohol Drinking, Hypertension and Renal Cell Carcinoma in Taiwan.},
journal = {Anticancer research},
year = {2026},
doi = {10.21873/anticanres.18240},
note = {PMID: 42373263},
}
TY - JOUR AU - Chang SY AU - Tsai HW AU - Wang BR AU - Yang YC AU - Chen JC AU - Tsai CW AU - Bau DT AU - Chang WS TI - Insights into Matrix Metalloproteinase-2 Genotypes, Smoking, Alcohol Drinking, Hypertension and Renal Cell Carcinoma in Taiwan. T2 - Anticancer research PY - 2026 DO - 10.21873/anticanres.18240 AN - PMID:42373263 ER -
BACKGROUND/AIM: Renal cell carcinoma (RCC) accounts for more than 90% of kidney malignancies worldwide. Matrix metalloproteinase-2 (MMP-2) has been reported to be dysregulated in multiple cancers. However, the relationship between MMP-2 genetic polymorphisms and RCC risk has rarely been investigated. This study aimed to evaluate the associations of two promoter polymorphisms, MMP-2 rs243865 and rs2285053, with RCC susceptibility in a Taiwanese population. MATERIALS AND METHODS: A hospital-based case-control study was conducted including 118 RCC patients and 590 cancer-free controls. Genotyping of MMP-2 rs243865 and rs2285053 was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: A significant association was observed between MMP-2 rs243865 and RCC susceptibility (p for trend=0.0077). Compared to the CC genotype, individuals carrying the TT genotype exhibited a markedly increased risk of RCC (OR=4.29, 95%CI=1.56-11.83, p=0.0069), whereas the CT genotype showed no significant effect (OR=1.31, 95%CI=0.80-2.16, p=0.3530). The T allele was also associated with elevated RCC risk (OR=1.71, 95%CI=1.15-2.54, p=0.0101). In contrast, rs2285053 showed no significant association with RCC. Stratified analyses revealed significant MMP-2 rs243865 genotype differences among subgroups defined by smoking, alcohol consumption, and hypertension status (p=0.0175, 0.0173, and 0.0063, respectively). CONCLUSION: MMP-2 rs243865, particularly the TT genotype, may serve as a genetic susceptibility marker for RCC and may interact with lifestyle and clinical factors including smoking, alcohol drinking, and hypertension. Further large-scale studies are warranted to validate these observations and clarify the biological mechanisms underlying MMP-2-mediated RCC carcinogenesis.